p21/p53, Cellular Growth Control and Genomic Integrity

  • W. S. El-Deiry
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 227)


In the short time since its discovery in 1993, the prototype cyclin-dependent kinase (CDK) inhibitor p21 (CIP1, Harper et al. 1993; WAF1, El-Deiry et al. 1993; p21, Xiong et al. 1993a; CAP20, Gu et al. 1993; SDI1, Noda et al. 1994; MDA6, Jiang et al. 1995) has become an intensely studied molecule. Much has been learned about its molecular structure, biochemical interactions, and physiological role. p21 is a focal point that integrates many types of signals that impact on processes of cell division and cell death. Since 1995 to date there have been over 600 references in Current Contents dealing with WAF1 or CIP1 and they are increasing at a rate of up to 25 per week. The p53 field which dates back to 1979 has had some 6000 references on Medline since 1993. This chapter will highlight some of the recent discoveries emphasizing the role of p21 and p53 in growth control and the maintenance of genomic integrity.


Human Papilloma Virus Nucleotide Excision Repair Genomic Integrity Increase Mutation Frequency Cellular Growth Control 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1998

Authors and Affiliations

  • W. S. El-Deiry
    • 1
  1. 1.Laboratory of Molecular Oncology and Cell Cycle Regulation, Howard Hughes Medical Institute, Department of Medicine, Genetics and Cancer CenterUniversity of Pennsylvania School of MedicinePhiladelphiaUSA

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