Uptake of Exogenous Gangliosides by the CNS?

  • H Rösner
  • C J Willibald
  • G Schwarzmann
  • H Rahmann
Conference paper
Part of the NATO ASI Series book series (volume 7)


Application in vivo of exogenous gangliosides have been reported to promote fibre sprouting and regeneration of damaged peripheral nerves (1,2,3) and to enhance recovery after CNS injury (4,5,6,7,8,9). Furthermore, it has been reported, that repeated injections of gangliosides had in some cases positive effects on recovery from chronical diseases of the nervous system in man (10,11). However, unlike in vitro, where the uptake, incorporation and metabolism of exogenous gangliosides has been well established (12, 13,14,15,18,19,20), there exists only a few studies concerning the fate of exogenous gangliosides in vivo (16,17,18,19,20,21). Particularly, it is an open question to what extend in vivo-injected gangliosides are incorporated by central nervous tissue. For this reason we studied the in vivo-fate of (3H-sph)-GD1a after injection into the eye bulb of chicken. This mode of application were chosen for deriving information concerning the metabolism and axonal transport of glycoconjugates in the optic system (22, 23,24,25,26,27) as well as the uptake of blood-distributed exogenous gangliosides.


Optic Nerve Axonal Transport Optic Lobe Neural Organ Central Nervous Tissue 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • H Rösner
    • 1
  • C J Willibald
    • 1
  • G Schwarzmann
    • 2
  • H Rahmann
    • 1
  1. 1.Institute of ZoologyUniversity of Stuttgart-HohenheimStuttgart 70Germany
  2. 2.Institute of Organic Chemistry and BiochemistryUniversity of BonnBonn 1Germany

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