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Effect of Veratrine on Ganglioside Biosynthesis in Cerebellar Cultures

  • U. Hinrichs
  • S. Thomsen
  • G. van Echten
  • K. Sandhoff
Conference paper
Part of the NATO ASI Series book series (volume 7)

Abstract

Gangliosides, characteristic surface components of all mammalian cells, are highly enriched in nervous tissues. Although there is some evidence for their involvement in physiological processes (Hakomori, 1981) the exact biological role of gangliosides as well as the regulation of their metabolism still remain obscure.

Keywords

Nervous Tissue Liquid Scintillation Counter Skin Fibroblast Scintillation Counter Human Skin Fibroblast 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. Hakomori SK (1981) Glycosphingolipids in cellular interaction, differentiation, and oncogenesis. Annu Rev Biochem 50: 733–764PubMedCrossRefGoogle Scholar
  2. Honerjäger P (1982) Cardioactive substances that prolong the open state of sodium-channels. Rev Physiol Biochem Pharmacol 92: 1–74PubMedCrossRefGoogle Scholar
  3. Ohta M, Narahasi T, and Keeler RF (1973) Effects of veratrum alkaloids on membrane potential and conductance of squid and giant axons. J Pharmacol Exp Ther 184: 143–154Google Scholar
  4. Sonderfeld S, Conzelmann E, Schwarzmann G, Burg J, Hinrichs U, and Sandhoff K (1985) Incorporation and metabolism of ganglioside GM2 in skin fibroblasts from normal and GM2 gangliosidosis subjects. Eur J Biochem 149: 247–255PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • U. Hinrichs
    • 1
  • S. Thomsen
    • 1
  • G. van Echten
    • 1
  • K. Sandhoff
    • 1
  1. 1.Institut für Organische Chemie und BiochemieUniversität BonnBonn 1Federal Republic of Germany

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