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The Arachidonate Cascade and Mouse Skin Tumor Promotion

  • Conference paper
Book cover Prostaglandins in Cancer Research

Part of the book series: Proceedings in Life Sciences ((LIFE SCIENCES))

Abstract

The observations of Janoff et al. (1970) and Marks et al. (1982) that the application of the tumor promoter TPA induces cytotoxicity, inflammation, and vascular permeability changes provided the basis for inquiry into the involvement of arachidonate metabolites in such manifestations and in the tumor promotion process. Mouse skin is one of the more commonly used organs in experimental carcinogenesis studies and has proved to be one of the best model systems for studying the multistage nature of carcinogenesis (Berenblum and Shubik 1947; Slaga et al. 1980a, 1981a). Skin tumors in mice can be readily induced by the sequential application of a subthreshold dose of a carcinogen (initiation stage) followed by repetitive treatment with a noncarcinogenic tumor promoter (promotion stage). Promotion is most often accomplished by using 12-O-tetradecanoyl phorbol-13-acetate (TPA), although a variety of agents have been identified as skin tumor promoters, including benzoyl peroxide, anthralin, and dihydroteleocidin B (Slaga 1984). Promotion can be further subdivided such that the appropriate sequential use of incomplete or partial promoters such as the calcium ionophore A-23187 (first stage promoter) and mezerein (second stage) can supplant the use of a complete promoter.

This work wa supported by NIH Grants CA-34443 and CA-42211.

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Abbreviations

TPA:

12-O-tetradecanoyl phorbol-13-acetate

ODC:

ornithine decarboxylase

PGs:

prostaglandins

NDGA:

nordihydroguaiaretic acid

HETE:

hydroxyeicosatetraenoic acid

HPETE:

hydroperoxyeicosatetraenoic acid

SOD:

superoxide dismutase

CuDIPS = Cu(II)(3,4:

diisopropyl salicylic acid)2

CL:

chemiluminescence.

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Authors and Affiliations

  1. Science Park-Research Division, University of Texas System Cancer Center, Smithville, TX, 78957, USA

    S. M. Fischer

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  1. S. M. Fischer
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Editors and Affiliations

  1. Department of Experimental Medicine, II University of Rome, Via O. Raimondo, 00173, Rome, Italy

    Enrico Garaci

  2. Institute of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133, Milan, Italy

    Rodolfo Paoletti

  3. Institute of Experimental Medicine, CNR, II University of Rome, Via O. Raimondo, 00173, Rome, Italy

    M. Gabriella Santoro

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© 1987 Springer-Verlag Berlin Heidelberg

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Fischer, S.M. (1987). The Arachidonate Cascade and Mouse Skin Tumor Promotion. In: Garaci, E., Paoletti, R., Santoro, M.G. (eds) Prostaglandins in Cancer Research. Proceedings in Life Sciences. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71904-2_4

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  • DOI: https://doi.org/10.1007/978-3-642-71904-2_4

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-71906-6

  • Online ISBN: 978-3-642-71904-2

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