Abstract
The anti-oestrogen tamoxifen increases the survival of breast cancer patients by 20% over a 6-year period (Nolvadex adjuvant trial organization, 1985). Although tamoxifen is thought to act via oestrogen receptors, some patients with oestrogen-receptor-negative mammary carcinomas have also responded, indicating that other mechanisms may be involved.
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Bennett A, Houghton J, Leaper DJ, Stamford IF (1979) Cancer growth, response to treatment and survival time in mice: beneficial effect of the prostaglandin synthesis inhibitor flurbiprofen. Prostaglandins 17: 179–191
Bennett A, Berstock DA, Carroll MA (1982) Increased survival of cancer-bearing mice treated with inhibitors of prostaglandin synthesis alone or with chemotherapy. Br J Cancer 45: 762–768
Hennam IP, Johnson DA, Newton JR, Collins WP (1974) Radioimmunoassay of prostaglandin F2α in peripheral venous plasma from men and women. Prostaglandins 5: 531–542
Hewitt H, Blake ER, Walder AS (1976) A critique of the evidence for active host defence against cancer, based on personal studies of 27 murine tumours of spontaneous origin. Br J Cancer 33: 241–259
Nolvadex Adjuvant Trial Organization NATO (1985) Controlled trial of tamoxifen as single adjuvent agent in management in early breast cancer. Lancet 836–40
Ritchie GAF (1980) The direct inhibition of prostaglandin synthetase of human breast cancer tumour tissue by tamoxifen. In: Henningsen B, Linder F, Steichele C (eds) Recent Results in Cancer Research: Endocrine Treatment of Breast Cancer. Springer, Berlin Heidelberg, New York, pp 96–101
Stamford IF, Carrol MA, Civier A, Hensby CN, Bennett A (1983) Identification of arachidonate metabolites in normal, benign and malignant mammary tissues. J Pharm Pharmacol 35: 48–49
Tavares IA, Sergis AN, Berry H, Bennett A (1986) Synovial and blood polymorphonuclear leuco-cytes from arthritic patients metabolise arachidonic acid similarly. Prog Lipid Res (in press)
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© 1987 Springer-Verlag Berlin Heidelberg
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Stamford, I.F. et al. (1987). Tamoxifen Has Little Effect on Cyclo-Oxygenase but Can Inhibit 5-Lipoxygenase. In: Garaci, E., Paoletti, R., Santoro, M.G. (eds) Prostaglandins in Cancer Research. Proceedings in Life Sciences. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71904-2_26
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DOI: https://doi.org/10.1007/978-3-642-71904-2_26
Publisher Name: Springer, Berlin, Heidelberg
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