Abstract
The thermodynamic properties of aqueous globular proteins are considered, both when at equilibrium in a heat bath and during enzymatic catalysis. It is recognized that they exhibit thermally driven conformational fluctuations of great complexity and on time scales that may be much faster than the enzyme turnover time. Yet conformational states of proteins can store free energy under macroscopically isothermal conditions. This requires that they possess special, collective, non-thermally excited modes both during enzymatic catalysis and, in particular, during free energy conservation. Electron transport phosphorylation and related membrane processes provide well-defined examples of this latter behavior.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
A. Ansari, J. Berendzen, S.F. Bowne, H. Frauenfelder, I.E.T. Iben, T.B. Sauke, E. Shyamsunder, and R.D. Young, Proc. Natl. Acad. Sci. U.S.A. 82, 5000–5004 (1985).
J.D. Barrow and J. Silk, The Left Hand of Creation, The Origin and Evolution of the Expanding Universe, Unwin, London, 1983.
J.A. Berzofsky, Science 229, 932–940 (1985).
H. Bilz, H. Büttner, and H. Fröhlich, Z. Naturforsch. 36b, 208–212 (1981).
L.A. Blumenfeld, Physics of Bioenergetic Processes, Springer, Heidelberg, 1983.
G. Careri, P. Fasella, and E. Gratton, Annu. Rev. Biophys. Bioeng. 8, 69–97 (1979).
G. Careri, M. Geraci, A. Giansanti, and J.A. Rupley, Proc. Natl. Acad. Sci. U.S.A. 82, 5342–5346 (1985).
G. Careri and J. Wyman, Proc. Natl. Acad. Sci. U.S.A. 81, 4386–4388 (1984).
F.L. Carter, Physica 10D, 175–194 (1984).
K.-C. Chou, Biophys. Chem. 20, 61–71 (1984).
A. Cooper, Prog. Biophys. Mol. Biol. 44, 181–214 (1984).
A.S. Davydov, “Energy transfer along alpha-helical proteins,” in Structure and Dynamics: Nucleic Acids and Proteins, E. Clementi and R.H. Sarma, Eds., Adenine Press, New York, 1983, pp 377–387.
E. Del Giudice, S. Doglia, M. Milani, and M.P. Fontana, Cell. Biophys. 6, 117–129 (1984).
S.W. Englander and N.R. Kallenback, Q. Rev. Biophys. 16, 521–655.
S.J. Ferguson, Biochim. Biophys. Acta 811, 47–95 (1985).
A.R. Fersht, Enzyme Structure and Mechanism, 2nd Ed., Freeman, San Francisco, 1985.
H. Fröhlich, Int. J. Quantum Chem. 2, 641–649 (1968).
H. Fröhlich, “Quantum mechanical concepts in biology,” in Proc. 1st Int. Conf. on Theoretical Physics and Biology, M. Marois, Ed., North Holland, Amsterdam, 1969, pp 13–22.
H. Fröhlich, Adv. Electron. Electron Phys. 53, 85–152 (1980).
H. Fröhlich and F. Kremer, Eds., Coherent Excitations in Biological Systems, Springer, Heidelberg, 1983.
F.R.N. Gurd and T.M. Rothgeb, Adv. Protein Chem. 33, 73–165 (1979).
H. Haken, Synergetics, Springer, Heidelberg, 1977.
C.M. Harris, G.D. Hitchens, and D.B. Kell, “Dielectric spectroscopy of microbial membrane systems,” in Charge and Field Effects in Biosystems, M.J. Allen and P.N.R. Usherwood, Eds., Abacus, Tunbridge Wells, 1984, pp 179–185.
C.M. Harris and D.B. Kell, Eur. Biophys. J. 13, 11–24 (1985).
G. D. Hitchens and D.B. Kell, Biochim. Biophys. Acta 766, 222–232 (1984). 244
R. Jaenicke, Angew. Chem. Int. Ed. Engl. 23, 395–413 (1984).
Jardetzky and R. King, Ciba Found. Symp. 93, 295–309 (1983).
W.P. Jencks, “What everyone wanted to know about tight binding and enzyme catalysis, but never thought of asking,” in Chemical Recognition in Biology, F. Chapeville and A.L. Haenni, Eds., Springer, Heidelberg, 1980, pp 1–25.
D.B. Kell, Trends Biochem. Sci. 7, 349 (1982).
D.B. Kell, Bioelectrochem. Bioenerg. 11, 405–415 (1983).
D.B. Kell and C.M. Harris, Eur. Biophys. J. 12, 181–197 (1985).
D.B. Kell and G.D. Hitchens, Faraday Discuss. Chem. Soc. 74, 377–388 (1982).
D.B. Kell and G.D. Hitchens, “Coherent properties of the membranous systems of electron transport phosphorylation,” in Coherent Excitation in Biological Systems, H. Fröhlich and F. Kremer, Eds., Springer, Heidelberg, 1983, pp 178–198.
D.B. Kell and H.V. Westerhoff, (1985), “Catalytic facilitation and membrane bioenergetics,” in Organized Multienzyme Systems: Catalytic Properties, G.R. Welch, Ed., Academic Press, New York, 1985, pp. 63–139.
G. Kemeny, Proc. Natl. Acad. Sci. U.S.A. 71, 2655–2657 (1974).
T.S. Kuhn, The Structure of Scientific Revolutions, Chicago University Press, Chicago, 1970.
P.S. Lomdahl, “Nonlinear dynamics of globular protein,” in Nonlinear Electrodynamics in Biological Systems, W.R. Adey and A.F. Larence, Eds., Plenum, New York, 1984, pp 143–154.
P.S. Lomdahl, S.P. Layne, and I.J. Bigio, Los Alamos Sci. 10, 2–31 (1984).
R. Lumry, (1980), “Dynamical aspects of small- molecule protein interactions,” in Bioenergetics and Thermodynamics: Model Systems, A. Braibanti, Ed., Reidel, Dordrecht, 1980, pp 435–452.
R. Lumry and R. Biltonen, (1969), “Thermodynamic and kinetic aspects of protein conformation in relation to physiological function,” in Structure and Stability of Biological Macromolecules, S.N. Timasheff and G.D. Fasman, Eds., Dekker, New York, 1969, pp 65–212.
J.A. McCammon, Rep. Progr. Phys. 47, 1–46 (1984).
C.W.F. McClare, J. Theor. Biol. 30, 1–34, (1971).
P. Mitchell, Biol. Rev. 41, 445–502, (1966).
M. Mutter, Angew. Chem. Int. Ed. Engl. 24, 639–653 (1985).
G. Nicolis and I. Prigogine, Self-organization in Non-equilibrium Systems, Wiley, Chichester, 1977.
D.G. Nicholls, Bioenergetics. An Introduction to the Chemiosmotic Theory, Academic Press, London, 1982.
H. A. Pohl, Coll. Phenom. 3, 221–244 (1981).
A.A. Ribeiro, R. King, and O. Jardetzky, (1983), “Rotational solitons in folded polypeptide chains,” in Conformation in Biology, R. Srinivasan and R.H. Sarma, Eds., Adenine Press, New York, 1983, pp 39–47.
D. Ringe and G.A. Petsko, Progr. Biophys. Mol. Biol. 45, 197–235 (1985).
E. Schrödinger, What is Life?, Cambridge University Press, Cambridge, 1944.
A. C. Scott, “Solitons on the alpha-helix protein,” in Structure and Dynamics: Nucleic Acids and Proteins, E. Clementi and R.H. Sarma, Eds., Adenine Press, New York, 1983, pp 389–404.
M.L. Sinnott, Chem. Brit. 17, 293–297 (1979).
B. Somogyi, G.R. Welch, and S. Damjanovich, Biochim. Biophys. Acta 768, 81–112 (1984).
S.J. Webb, Phys. Rep. 60, 201–224 (1980).
G.R. Welch, Ed., The Fluctuating Enzyme, Wiley, New York, 1986.
G.R. Welch and D.B. Kell, “Not just catalysts. The bioenergetics of molecular machines,” in The Fluctuating Enzyme, G.R. Welch, Ed., Wiley, New York, 1986.
G. R. Welch, B. Somogyi, and S. Damjanovich, Progr. Biophys. Mol. Biol. 39, 109–146 (1982).
H. V. Westeroff, B.A. Melandri, G. Venturoli, G.F. Azzone, and D.B. Kell, Biochim. Biophys. Acta 768, 257–292 (1984).
R.J.P. Williams and G.R. Moore, Trends Biochem. Sci. 10, 96–97 (1985).
S. Yomosa, J. Phys. Soc. Jpn. 52, 1866–1873 (1983).
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1987 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Kell, D.B. (1987). Non-Thermally Excited Modes and Free Energy Transduction in Proteins and Biological Membranes. In: Barrett, T.W., Pohl, H.A. (eds) Energy Transfer Dynamics. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71867-0_22
Download citation
DOI: https://doi.org/10.1007/978-3-642-71867-0_22
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-17502-5
Online ISBN: 978-3-642-71867-0
eBook Packages: Springer Book Archive