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Differentiation of B Lymphocytes pp 75–94Cite as

Expression of the Immunoglobulin Heavy-Chain Variable Gene Repertoire

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Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 135))

Abstract

A major challenge in immunology is the elucidation of the cellular and molecular mechanisms which determine the expressed antibody repertoire. A large body of knowledge concerning murine antibody gene organization and diversity has been accumulated. However, the underlying processes governing usage of these genes remains in question. Knowledge of the mechanisms which regulate immunoglobulin variable (V) gene rearrangement and the relative expression of the various V gene families in developing B–cell populations may be crucial to an understanding of generation of the antibody repertoire in normal as well as disease states. Current investigation of human V H gene organization and diversity will evwntually allow extension of information gained about the murine repertoire to studies of V H gene usage in humans.

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Author information

Authors and Affiliations

  1. Department of Biochemistry and Molecular Biophysics, Columbia University College of Physicians and Surgeons, 630 West 168 Street, New York, NY, 10032, USA

    B. A. Malynn, J. E. Berman, G. D. Yancopoulos & F. W. Alt

  2. Department of Microbiology, Mount Sinai School of Medicine, New York, NY, USA

    C. A. Bona

Authors
  1. B. A. Malynn
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  2. J. E. Berman
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  3. G. D. Yancopoulos
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  4. C. A. Bona
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  5. F. W. Alt
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Editor information

Editors and Affiliations

  1. Basel Institute for Immunology, Grenzacherstrasse 487, CH-4058, Basel, Switzerland

    Christopher J. Paige  & Roland H. Gisler  & 

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© 1987 Springer-Verlag Berlin Heidelberg

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Malynn, B.A., Berman, J.E., Yancopoulos, G.D., Bona, C.A., Alt, F.W. (1987). Expression of the Immunoglobulin Heavy-Chain Variable Gene Repertoire. In: Paige, C.J., Gisler, R.H. (eds) Differentiation of B Lymphocytes. Current Topics in Microbiology and Immunology, vol 135. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71851-9_6

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  • DOI: https://doi.org/10.1007/978-3-642-71851-9_6

  • Publisher Name: Springer, Berlin, Heidelberg

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