Cancer Risks pp 171-180 | Cite as

Viruses in Human Tumors

  • H. zur Hausen
Conference paper


Table 1 lists the possible interactions of viruses in oncogenesis and emphasizes the role of human pathogenic viruses. The majority of tumor viruses known today insert their genetic material into the host cell nucleus, where it persists. The expression of at least one viral function appears to be a prerequisite for the maintenance of the transformed state.


Cervical Cancer Herpes Simplex Virus Type Genital Wart Penile Cancer Condyloma Acuminata 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Almeida JD, Oricl JD, Stannard LM (1969) Characterization of the virus found in human genital warts. Microbios 3:225–229Google Scholar
  2. Beaudenon S, Kremsdorf D, Croissant O, Jablonska S, Wain-Hobson S, Orth G (1986) A novel type of human papillomavirus associated with genital neoplasias. Nature 321:246–249PubMedCrossRefGoogle Scholar
  3. Boshart M, Gissmann L, Ikenberg H, Keinheinz A, Scheurlen W, zur Hausen H (1984) A new type of papillomavirus DNA, its presence in genital cancer biopsies and in cell lines derived from cervical cancer. EMBO J 3:1151–1157PubMedGoogle Scholar
  4. Ciuffo G (1907) Innesto positivo con filtrato di verruca vulgäre. Giorn Ital Mal Venereol 48:12–17Google Scholar
  5. Crum CP, Mitao M, Levine RU, Silverstein S (1985) Cervical papillomaviruses segregate within morphologically distinct precancerous lesions. J Virol 54:675–681PubMedGoogle Scholar
  6. de Villiers E-M, Gissmann L, zur Hausen H (1981) Molecular cloning of viral DNA from human genital warts. J Virol 40:932–935PubMedGoogle Scholar
  7. Dürst M, Gissmann L, Ikenberg H, zur Hausen H (1983) A papillomavirus DNA from a cervical carcinoma and its prevalence in cancer biopsy samples from different geographic regions. Proc Natlo Acad Sci USA 80:3812–3815CrossRefGoogle Scholar
  8. Dürst M, Kleinheinz A, Hotz M, Gissmann L (1985) The physical state of human papillomavirus type 16 DNA in benign and malignant genital tumors. J Gen Virol 66:1515–1522PubMedCrossRefGoogle Scholar
  9. Duff R, Rapp F (1973) Oncogenic transformation of hamster embryo cells after exposure to inactivated herpes simplex virus type I. J Virol 12:209–217PubMedGoogle Scholar
  10. Gissmann L, zur Hausen H (1976) Human papillomaviruses: physical mapping and genetic heterogeneity. Proc Natl Acad Sci USA 73:1310–1313PubMedCrossRefGoogle Scholar
  11. Gissmann L, zur Hausen H (1980) Partial characterization of viral DNA from human genital warts (condylomata acuminata). Int J Cancer 25:605–609PubMedCrossRefGoogle Scholar
  12. Gissmann L, Pfister H, zur Hausen H (1977) Human papillomaviruses (HPV): characterization of four different isolates. Virology 76:569–580PubMedCrossRefGoogle Scholar
  13. Gissmann L, Diehl V, Schulz-Coulon H, zur Hausen H (1982) Molecular cloning and characterization of human papillomavirus DNA from a laryngeal papilloma. J Virol 44:393–400PubMedGoogle Scholar
  14. Gissmann L, Wolnik H, Ikenberg H, Koldovsky U, Schnüren HG, zur Hausen H (1983) Human papillomavirus types 6 and 11 sequences in genital and laryngeal papillomas and in some cervical cancer biopsies. Proc Natl Acad Sci USA 80:560–563PubMedCrossRefGoogle Scholar
  15. Heilbronn R, Schlehofer JR, Yalkinoglu AÖ, zur Hausen H (1985) Selective DNA amplification induced by carcinogens (initiators): evidence for a role of proteases and DNA polymerase alpha. Int J Cancer 36:85–91PubMedCrossRefGoogle Scholar
  16. Ikenberg H, Gissmann L, Gross G, Grussendorf-Conen E-I, zur Hausen H (1983) Human papillomavirus type 16 related DNA in genital Bowen’s disease and in bowenoid papulosis. Int J Cancer 32:563–565PubMedCrossRefGoogle Scholar
  17. Kreider JW, Howett MK, Wolfe SA, Bartlett GL, Zaino RJ, Sedlacek TV, Mortel L (1985) Morphological transformation in vivo of human uterine cervix with papillomavirus from condylomata acuminata. Nature 317:639–641PubMedCrossRefGoogle Scholar
  18. Law MF, Lancaster WD, Howley PM (1979) Conserved polynucleotide sequences among the genomes of papillomaviruses. J Virol 32:199–211PubMedGoogle Scholar
  19. Lorincz AT, Lancaster WD, Temple GF (1985) Detection and characterization of a new type of human papillomavirus. J Cell Biochem [Suppl] 9c:75Google Scholar
  20. Meisels A, Roy M, Fortier M, Morin C, Casas-Cordero M, Shah KV, Turgeon H (1981) Human papillomavirus infection of the cervix: the atypical condyloma. Acta Cytol 25:7–16PubMedGoogle Scholar
  21. Mincheva A, Gissmann L, zur Hausen H (1986) Chromosomal integration sites of human papillomavirus DNA in three cervical cancer cell lines mapped by in-situ hybridization. (Submitted for publication)Google Scholar
  22. Mounts P, Shah KV, Kashima H (1982) Viral etiology of juvenile and adult onset squamous papilloma of the larynx. Proc Natl Acad Sci USA 79:5425–5429PubMedCrossRefGoogle Scholar
  23. Nahmias AJ, Josey WE, Naib ZM, Luce CF, Guest BA (1970) Antibodies to herpes virus hominis types I and II in humans: II. Women with cervical cancer. Am J Epidemiol 91:547–552PubMedGoogle Scholar
  24. Orth G, Favre M, Croissant O (1977) Characterization of a new type of human papillomavirus that causes skin warts. J Virol 24:108–120PubMedGoogle Scholar
  25. Orth G, Favre M, Breitburd F, Croissant O, Jablonska S, Obalek S, Jarzabek-Chorzelska M, Rzesa G (1980) Epidermodysplasia verruciformis: a model for the role of papillomaviruses in human cancer. In: Essex M, Todaro G, zur Hausen H (eds) Viruses in naturally occurring cancers. Cold Spring Harbor, NY, pp 259–282Google Scholar
  26. Rawls WE, Tompkins WAF, Figueroa ME, Melnick JL (1968) Herpes simplex virus type 2: association with carcinoma of the cervix. Science 161:1255–1256PubMedCrossRefGoogle Scholar
  27. Rigoni-Itern D (1842) Fatti statistici relativi alle malattie cancrose. Giornale Service Progr Pathol Terap Ser 2:507–517Google Scholar
  28. Rotkins ID (1973) A comparison review of key epidemiological studies in cervical cancer related to current searches for transmissible agents. Cancer Res 33:1353–1367Google Scholar
  29. Rowson KEK, Mahy BWJ (1967) Human papova (wart) virus. Bacteriol Rev 31:110–131PubMedGoogle Scholar
  30. Schlehofer JR, zur Hausen H (1982) Induction of mutations within the host cell genome by partially inactivated herpes simplex virus type 1. Virology 122:471–475PubMedCrossRefGoogle Scholar
  31. Schlehofer JR, Gissmann L, Matz B, zur Hausen H (1983) Herpes simplex virus induced amplification of SV 40 sequences in transformed Chinese hamster cells. Int J Cancer 32:99–103PubMedCrossRefGoogle Scholar
  32. Schlehofer JR, Ehrbar M, zur Hausen H (1986) Vaccinia virus, herpes simplex virus and carcinogens induce DNA amplification in a human cell line and support replication of a helper-dependent parvovirus. Virology 152:110–117PubMedCrossRefGoogle Scholar
  33. Schneider-Gaedicke A, Schwarz E (1986) Different human cervical carcinoma cell lines show similar transcription patterns of human papillomavirus type 18 genes. EMBO J 5:2285–2292Google Scholar
  34. Schwarz E, Freese UK, Gissmann L, Mayer W, Roggenbuck B, zur Hausen H (1985) Structure and transcription of human papillomavirus sequences in cervical carcinoma cells. Nature 314:111–114PubMedCrossRefGoogle Scholar
  35. Stanbridge EJ, Der CJ, Doersen C-J, Nishimi RY, Peehl DM, Weissman BE, Wilkinson JE (1982) Human cell hybrids: analysis of transformation and tumorigenieity. Science 215:252–259PubMedCrossRefGoogle Scholar
  36. zur Hausen H (1977a) Human papillomaviruses and their possible role in squamous cell carcinomas. Curr Top Microbiol Immunol 78:1–30CrossRefGoogle Scholar
  37. zur Hausen H (1977b) Cell-virus gene balance hypothesis of carcinogenesis. Behring Inst Mitt 61:23–30Google Scholar
  38. zur Hausen H (1980) The role of viruses in human tumors. Adv Cancer Res 33:77–107PubMedCrossRefGoogle Scholar
  39. zur Hausen H (1982) Human genital cancer: synergism between two virus infections or synergism between a virus infection and initiating events. Lancet 2:1370–1373PubMedCrossRefGoogle Scholar
  40. zur Hausen H (1983) Herpes simplex virus in human genital cancer. Int Rev Exp Pathol 25:307–326PubMedGoogle Scholar
  41. zur Hausen H (1986) Intracellular surveillance of persisting viral infections: human genital cancer resulting from a failing cellular control of papilloma-virus gene expression. Lancet 2:489–491PubMedCrossRefGoogle Scholar
  42. zur Hausen H, Schneider A (1986) The role of papillomaviruses in human anogenital cancer. In: Howley PM, Salzman NP (eds) The papovaviridae, the papillomaviruses. Plenum, New York (to be published)Google Scholar
  43. zur Hausen H, Schulte-Holthausen H (1970) Presence of EB virus nucleic acid homology in a “virusfree” line of Burkitt tumor cells. Nature 227:245–248PubMedCrossRefGoogle Scholar
  44. zur Hausen H, Schulte-Holthausen H, Klein G, Henle W, Henle G, Chifford P, Santesson L (1970) EBV DNA in Burkitt tumours and anaplastic carcinomas of the nasopharynx. Nature 228:1056–1058PubMedCrossRefGoogle Scholar
  45. zur Hausen H, Meinhof W, Scheiber W, Bornkamm GW (1974) Attempts to detect virus specific DNA sequences in human tumors: I. Nucleic acid hybridizations with complementary RNA of human wart virus. Int J Cancer 13:650–656PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • H. zur Hausen

There are no affiliations available

Personalised recommendations