Skip to main content
SpringerLink
Log in

Viruses in Human Tumors

  • Conference paper
Cancer Risks

  • 48 Accesses

Abstract

Table 1 lists the possible interactions of viruses in oncogenesis and emphasizes the role of human pathogenic viruses. The majority of tumor viruses known today insert their genetic material into the host cell nucleus, where it persists. The expression of at least one viral function appears to be a prerequisite for the maintenance of the transformed state.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Almeida JD, Oricl JD, Stannard LM (1969) Characterization of the virus found in human genital warts. Microbios 3:225–229

    Google Scholar 

  • Beaudenon S, Kremsdorf D, Croissant O, Jablonska S, Wain-Hobson S, Orth G (1986) A novel type of human papillomavirus associated with genital neoplasias. Nature 321:246–249

    Article  PubMed  CAS  Google Scholar 

  • Boshart M, Gissmann L, Ikenberg H, Keinheinz A, Scheurlen W, zur Hausen H (1984) A new type of papillomavirus DNA, its presence in genital cancer biopsies and in cell lines derived from cervical cancer. EMBO J 3:1151–1157

    PubMed  CAS  Google Scholar 

  • Ciuffo G (1907) Innesto positivo con filtrato di verruca vulgäre. Giorn Ital Mal Venereol 48:12–17

    Google Scholar 

  • Crum CP, Mitao M, Levine RU, Silverstein S (1985) Cervical papillomaviruses segregate within morphologically distinct precancerous lesions. J Virol 54:675–681

    PubMed  CAS  Google Scholar 

  • de Villiers E-M, Gissmann L, zur Hausen H (1981) Molecular cloning of viral DNA from human genital warts. J Virol 40:932–935

    PubMed  Google Scholar 

  • Dürst M, Gissmann L, Ikenberg H, zur Hausen H (1983) A papillomavirus DNA from a cervical carcinoma and its prevalence in cancer biopsy samples from different geographic regions. Proc Natlo Acad Sci USA 80:3812–3815

    Article  Google Scholar 

  • Dürst M, Kleinheinz A, Hotz M, Gissmann L (1985) The physical state of human papillomavirus type 16 DNA in benign and malignant genital tumors. J Gen Virol 66:1515–1522

    Article  PubMed  Google Scholar 

  • Duff R, Rapp F (1973) Oncogenic transformation of hamster embryo cells after exposure to inactivated herpes simplex virus type I. J Virol 12:209–217

    PubMed  CAS  Google Scholar 

  • Gissmann L, zur Hausen H (1976) Human papillomaviruses: physical mapping and genetic heterogeneity. Proc Natl Acad Sci USA 73:1310–1313

    Article  PubMed  CAS  Google Scholar 

  • Gissmann L, zur Hausen H (1980) Partial characterization of viral DNA from human genital warts (condylomata acuminata). Int J Cancer 25:605–609

    Article  PubMed  CAS  Google Scholar 

  • Gissmann L, Pfister H, zur Hausen H (1977) Human papillomaviruses (HPV): characterization of four different isolates. Virology 76:569–580

    Article  PubMed  CAS  Google Scholar 

  • Gissmann L, Diehl V, Schulz-Coulon H, zur Hausen H (1982) Molecular cloning and characterization of human papillomavirus DNA from a laryngeal papilloma. J Virol 44:393–400

    PubMed  CAS  Google Scholar 

  • Gissmann L, Wolnik H, Ikenberg H, Koldovsky U, Schnüren HG, zur Hausen H (1983) Human papillomavirus types 6 and 11 sequences in genital and laryngeal papillomas and in some cervical cancer biopsies. Proc Natl Acad Sci USA 80:560–563

    Article  PubMed  CAS  Google Scholar 

  • Heilbronn R, Schlehofer JR, Yalkinoglu AÖ, zur Hausen H (1985) Selective DNA amplification induced by carcinogens (initiators): evidence for a role of proteases and DNA polymerase alpha. Int J Cancer 36:85–91

    Article  PubMed  CAS  Google Scholar 

  • Ikenberg H, Gissmann L, Gross G, Grussendorf-Conen E-I, zur Hausen H (1983) Human papillomavirus type 16 related DNA in genital Bowen’s disease and in bowenoid papulosis. Int J Cancer 32:563–565

    Article  PubMed  CAS  Google Scholar 

  • Kreider JW, Howett MK, Wolfe SA, Bartlett GL, Zaino RJ, Sedlacek TV, Mortel L (1985) Morphological transformation in vivo of human uterine cervix with papillomavirus from condylomata acuminata. Nature 317:639–641

    Article  PubMed  CAS  Google Scholar 

  • Law MF, Lancaster WD, Howley PM (1979) Conserved polynucleotide sequences among the genomes of papillomaviruses. J Virol 32:199–211

    PubMed  CAS  Google Scholar 

  • Lorincz AT, Lancaster WD, Temple GF (1985) Detection and characterization of a new type of human papillomavirus. J Cell Biochem [Suppl] 9c:75

    Google Scholar 

  • Meisels A, Roy M, Fortier M, Morin C, Casas-Cordero M, Shah KV, Turgeon H (1981) Human papillomavirus infection of the cervix: the atypical condyloma. Acta Cytol 25:7–16

    PubMed  CAS  Google Scholar 

  • Mincheva A, Gissmann L, zur Hausen H (1986) Chromosomal integration sites of human papillomavirus DNA in three cervical cancer cell lines mapped by in-situ hybridization. (Submitted for publication)

    Google Scholar 

  • Mounts P, Shah KV, Kashima H (1982) Viral etiology of juvenile and adult onset squamous papilloma of the larynx. Proc Natl Acad Sci USA 79:5425–5429

    Article  PubMed  CAS  Google Scholar 

  • Nahmias AJ, Josey WE, Naib ZM, Luce CF, Guest BA (1970) Antibodies to herpes virus hominis types I and II in humans: II. Women with cervical cancer. Am J Epidemiol 91:547–552

    PubMed  CAS  Google Scholar 

  • Orth G, Favre M, Croissant O (1977) Characterization of a new type of human papillomavirus that causes skin warts. J Virol 24:108–120

    PubMed  CAS  Google Scholar 

  • Orth G, Favre M, Breitburd F, Croissant O, Jablonska S, Obalek S, Jarzabek-Chorzelska M, Rzesa G (1980) Epidermodysplasia verruciformis: a model for the role of papillomaviruses in human cancer. In: Essex M, Todaro G, zur Hausen H (eds) Viruses in naturally occurring cancers. Cold Spring Harbor, NY, pp 259–282

    Google Scholar 

  • Rawls WE, Tompkins WAF, Figueroa ME, Melnick JL (1968) Herpes simplex virus type 2: association with carcinoma of the cervix. Science 161:1255–1256

    Article  PubMed  CAS  Google Scholar 

  • Rigoni-Itern D (1842) Fatti statistici relativi alle malattie cancrose. Giornale Service Progr Pathol Terap Ser 2:507–517

    Google Scholar 

  • Rotkins ID (1973) A comparison review of key epidemiological studies in cervical cancer related to current searches for transmissible agents. Cancer Res 33:1353–1367

    Google Scholar 

  • Rowson KEK, Mahy BWJ (1967) Human papova (wart) virus. Bacteriol Rev 31:110–131

    PubMed  CAS  Google Scholar 

  • Schlehofer JR, zur Hausen H (1982) Induction of mutations within the host cell genome by partially inactivated herpes simplex virus type 1. Virology 122:471–475

    Article  PubMed  CAS  Google Scholar 

  • Schlehofer JR, Gissmann L, Matz B, zur Hausen H (1983) Herpes simplex virus induced amplification of SV 40 sequences in transformed Chinese hamster cells. Int J Cancer 32:99–103

    Article  PubMed  CAS  Google Scholar 

  • Schlehofer JR, Ehrbar M, zur Hausen H (1986) Vaccinia virus, herpes simplex virus and carcinogens induce DNA amplification in a human cell line and support replication of a helper-dependent parvovirus. Virology 152:110–117

    Article  PubMed  CAS  Google Scholar 

  • Schneider-Gaedicke A, Schwarz E (1986) Different human cervical carcinoma cell lines show similar transcription patterns of human papillomavirus type 18 genes. EMBO J 5:2285–2292

    CAS  Google Scholar 

  • Schwarz E, Freese UK, Gissmann L, Mayer W, Roggenbuck B, zur Hausen H (1985) Structure and transcription of human papillomavirus sequences in cervical carcinoma cells. Nature 314:111–114

    Article  PubMed  CAS  Google Scholar 

  • Stanbridge EJ, Der CJ, Doersen C-J, Nishimi RY, Peehl DM, Weissman BE, Wilkinson JE (1982) Human cell hybrids: analysis of transformation and tumorigenieity. Science 215:252–259

    Article  PubMed  CAS  Google Scholar 

  • zur Hausen H (1977a) Human papillomaviruses and their possible role in squamous cell carcinomas. Curr Top Microbiol Immunol 78:1–30

    Article  Google Scholar 

  • zur Hausen H (1977b) Cell-virus gene balance hypothesis of carcinogenesis. Behring Inst Mitt 61:23–30

    Google Scholar 

  • zur Hausen H (1980) The role of viruses in human tumors. Adv Cancer Res 33:77–107

    Article  PubMed  Google Scholar 

  • zur Hausen H (1982) Human genital cancer: synergism between two virus infections or synergism between a virus infection and initiating events. Lancet 2:1370–1373

    Article  PubMed  Google Scholar 

  • zur Hausen H (1983) Herpes simplex virus in human genital cancer. Int Rev Exp Pathol 25:307–326

    PubMed  Google Scholar 

  • zur Hausen H (1986) Intracellular surveillance of persisting viral infections: human genital cancer resulting from a failing cellular control of papilloma-virus gene expression. Lancet 2:489–491

    Article  PubMed  Google Scholar 

  • zur Hausen H, Schneider A (1986) The role of papillomaviruses in human anogenital cancer. In: Howley PM, Salzman NP (eds) The papovaviridae, the papillomaviruses. Plenum, New York (to be published)

    Google Scholar 

  • zur Hausen H, Schulte-Holthausen H (1970) Presence of EB virus nucleic acid homology in a “virusfree” line of Burkitt tumor cells. Nature 227:245–248

    Article  PubMed  Google Scholar 

  • zur Hausen H, Schulte-Holthausen H, Klein G, Henle W, Henle G, Chifford P, Santesson L (1970) EBV DNA in Burkitt tumours and anaplastic carcinomas of the nasopharynx. Nature 228:1056–1058

    Article  PubMed  Google Scholar 

  • zur Hausen H, Meinhof W, Scheiber W, Bornkamm GW (1974) Attempts to detect virus specific DNA sequences in human tumors: I. Nucleic acid hybridizations with complementary RNA of human wart virus. Int J Cancer 13:650–656

    Article  PubMed  Google Scholar 

Download references

Authors
  1. H. zur Hausen
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Institut für Experimentelle Pathologie, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D-6900, Heidelberg, Germany

    Peter Bannasch

Rights and permissions

Reprints and permissions

Copyright information

© 1987 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

zur Hausen, H. (1987). Viruses in Human Tumors. In: Bannasch, P. (eds) Cancer Risks. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71843-4_14

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-71843-4_14

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-17465-3

  • Online ISBN: 978-3-642-71843-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation