Retinal Axons and the Basal Lamina
Fish and amphibians continue to add new neurons for years after they hatch and begin to live independently. This post-hatching neurogenesis has been studied mostly in the visual system, particularly in the retina. The continuous addition of new neurons to a retina that was already functioning adequately presents a number of interesting developmental questions, among which is how the axons of the retinal ganglion cells find their way to the brain. In the process of asking that question, in fish, my collaborators and I discovered that the new axons all grow along the basal lamina that surrounds the central nervous system. This physical association between a nerve cell and a part of the extracellular matrix is a very appropriate one to be discussed in this particular workshop.
KeywordsOptic Nerve Growth Cone Basal Lamina Trochlear Nerve Glia Limitans
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