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Radioimmunoassay of Drugs and Neurotransmitters

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Radioimmunoassay in Basic and Clinical Pharmacology

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 82))

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Abstract

Pharmacologists pose a number of questions for themselves regarding drugs. They are interested in the role of absorption, distribution, metabolism, excretion, and localization of the compound. In order to answer these questions, it is necessary that methods be available, but these methods must also have the attributes of high sensitivity, specificity, and reproducibility. An added attribute of an assay would be if the procedure had a simplicity that neither required extraction from biologic fluids nor column chromatography nor high pressure liquid chromatography instrumentation currently available. The radioimmunoassay techniques as developed by Berson and Yalow (1959) possess most of the attributes enumerated above. However, it needs to be emphasized that the specificity of the assay is not absolute.

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Authors
  1. S. Spector
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Editors and Affiliations

  1. Institute of Pharmacology, Catholic University of the Sacred Heart, Largo Francesco Vito, 1, I-00168, Rome, Italy

    Carlo Patrono (Professor of Molecular Pharmacology) (Professor of Molecular Pharmacology)

  2. Institute of Pharmacology and Toxicology, Ruhr-University Bochum Im Lottental, P.O. Box 102148, D-4630, Bochum 1, Germany

    Bernhard A. Peskar (Professor of Pharmacology and Toxicology) (Professor of Pharmacology and Toxicology)

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© 1987 Springer-Verlag Berlin Heidelberg

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Spector, S. (1987). Radioimmunoassay of Drugs and Neurotransmitters. In: Patrono, C., Peskar, B.A. (eds) Radioimmunoassay in Basic and Clinical Pharmacology. Handbook of Experimental Pharmacology, vol 82. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71809-0_24

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  • DOI: https://doi.org/10.1007/978-3-642-71809-0_24

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-71811-3

  • Online ISBN: 978-3-642-71809-0

  • eBook Packages: Springer Book Archive

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