Hormonal Control of Extracellular Calcium

  • I. MacIntyre
  • M. Zaidi
  • C. Milet
  • P. J. R. Bevis
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 83)

Abstract

Despite wide differences in calcium intake, plasma calcium is maintained with remarkable constancy. Approximately half of total plasma calcium is ionised and the remainder is largely bound to plasma albumin. Extracellular calcium concentration is more than 1000-fold greater than the critical intracellular concentration; a major change in the former would almost certainly be followed by gross disturbances in cellular metabolism, eventually leading to death. To prevent this, a set of interlocking hormonal mechanisms have evolved in vertebrates. These have been reviewed here with particular reference to the major clinical consequences of their disturbance and therapeutic approaches used for their correction.

Keywords

Osteoporosis Prolactin Colchicine Hyperparathyroidism Carboxy 

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References

  1. Amara SG, Jonas V, Rosenfeld MG, Ong ES, Evans RM (1982) Alternative RNA processing in calcitonin gene expression generates mRNAs encoding different polypeptide products. Nature 298:240–244PubMedCrossRefGoogle Scholar
  2. Amara SG, Arriza JL, Leff SE, Swanson LW, Evans RM, Rosenfeld MG (1985) Expression in brain of messenger RNA encoding a novel neuropeptide homologous to calcitonin gene-related peptide. Science 229:1094–1097PubMedCrossRefGoogle Scholar
  3. Arnaud CD, Goldsmith RS, Bordier PJ, Sizemore GW (1974) Influence of immunoheterogenaeity of circulating parathyroid hormone on results of radioimmunoassay of serum in man. Am J Med 56:785–793PubMedCrossRefGoogle Scholar
  4. Aurbach GD, Chase LD (1976) Cyclic nucleotides and biochemical actions of parathyroid hormone and calcitonin. In: Greep RO, Astwood EB (eds) Handbook of physiology. Endocrinology. American Physiological Society, Washington DC, pp 353–381Google Scholar
  5. Avioli LV, Krane SM (1978) Metabolic bone disease, vol 2. Academic, New YorkGoogle Scholar
  6. Bevis PJR, MacIntyre I, Morris HR, Zaidi M (1986 a) On the presence of a potent vasodilator calcitonin gene-related peptide in rat plasma. J Physiol (Lond) 376:24Google Scholar
  7. Bevis PJR, MacIntyre I, Zaidi M (1986 b) Further evidence for the neural release of plasma calcitonin gene-related peptide. Br J Pharmacol 88:314Google Scholar
  8. Bevis PJR, Zaidi M, Lynch C, Beacham J, Chambers TJ, MacIntyre I (1986 c) Human beta-calcitonin gene related peptide inhibits osteoclastic bone resorption and lowers plasma calcium. Bone (in press)Google Scholar
  9. Boyle IT, Gray RW, DeLuca HF (1971) Regulation by calcium of in vivo synthesis of 1,25-dihydroxycholecalciferol and 24,25-dihydroxycholecalciferol. Proc Natl Acad Sci USA 58:2131–2134CrossRefGoogle Scholar
  10. Brain SD, Williams TJ, Tippins JR, Morris HR, MacIntyre I (1985) Calcitonin gene-related peptide is a potent vasodilator. Nature 313:54–56PubMedCrossRefGoogle Scholar
  11. Brain SD, MacIntyre I, Williams TJ (1986) A second form of human calcitonin gene-related peptide which is a potent vasodilator. Eur J Pharmacol 124:349–352PubMedCrossRefGoogle Scholar
  12. Broadus AE, Goltzman D, Webbs AC, Kronenberg HM (1985) Messenger ribonucleic acid from tumors associated with humoral hypercalcemia of malignancy directs the synthesis of a secretory parathyroid hormone-like peptide. Endocrinology 117:1661–1666PubMedCrossRefGoogle Scholar
  13. Canterbury JM, Reiss E (1972) Multiple immunoreactive molecular forms of parathyroid hormone in human serum. Proc Soc Exp Biol Med 140:1393–1398PubMedGoogle Scholar
  14. Care AD (1970) The effects of pancreozymin and secretin on calcitonin release. Fed Proc 29:253Google Scholar
  15. Chambers TJ (1982) Pathobiology of the osteoclast. J Clin Pathol 38:214–252Google Scholar
  16. Chambers TJ, Moore A (1983) The sensitivity of isolated osteoclasts to morphological transformation by calcitonin. J Clin Endocrinol Metab 57:819–824PubMedCrossRefGoogle Scholar
  17. Chambers TJ, Athanasou NA, Fuller K (1984) Effect of parathyroid hormone and calcitonin on the cytoplasmic spreading of isolated osteoclasts. J Endocrinol 102:281–286PubMedCrossRefGoogle Scholar
  18. Chambers TJ, McSheehy PMJ, Thomson BM, Fuller K (1985 a) The effect of calcium-regulating hormones and prostaglandins on bone resorption by osteoclasts disaggregated from neonatal rabbit bones. Endocrinology 60:234–239CrossRefGoogle Scholar
  19. Chambers TJ, Fuller K, McSheehy PMJ, Pringle JAS (1985 b) The effect of calcium regulating hormones on bone resorption by isolated human osteoclastoma cells. J Pathol 145:297–305PubMedCrossRefGoogle Scholar
  20. Chase LR, Aurbach GD (1967) Parathyroid function of the renal excretion of 3′,5′-adenylic acid. Proc Natl Acad Sci USA 58:518–525PubMedCrossRefGoogle Scholar
  21. Chase LR, Aurbach GD (1968) Renal adenyl cyclase: anatomical separation of sites sensitive to parathyroid hormone and vasopressin. Science 159:545–547PubMedCrossRefGoogle Scholar
  22. Cooper CW, Schwesinger WH, Mahgoub AM, Ontjes DA (1971) Thyrocalcitonin stimulation of secretion by pentagastrin. Science 172:1238–1240PubMedCrossRefGoogle Scholar
  23. Copp DH, Cameron EC, Cheney BA, Davidson AGF, Henze KG (1962) Evidence for calcitonin — a new hormone from the parathyroid that lowers blood calcium. Endocrinology 70:638–649PubMedCrossRefGoogle Scholar
  24. Crawford A, Evans DB, Skjodt H, Beresford JN, MacIntyre I, Russell RGG (1986) Effect of human calcitonin gene-related peptide on human bone-derived cells in culture. Bone 7:157–158CrossRefGoogle Scholar
  25. Fenwick JC (1982) Some evidence concerning the nature of the hypocalcemic factor in the Stannius corpuscles. In: Oguro C, Pang PKT (eds) Comparative endocrinology of calcium regulation. Japan Scientific Societies Press, Tokyo, pp 167–172Google Scholar
  26. Fischer JA, Binswanger U, Dietrich FM (1974) Human parathyroid hormone: immunological characterization of antibodies against a glandular extract and the synthetic amino-terminal fragments 1–12 and their use in the determination of immunoreactive hormone in human sera. J Clin Invest 54:1382–1394PubMedCrossRefGoogle Scholar
  27. Fontaine M (1964) Corpuscles de Stannius et régulation ionique (Ca, K, Na) du milieu interieur de l’anguille (Anguilla anguilla L.). CR Seances Acad Sci [III] 259:875–878Google Scholar
  28. Foster GV, Baghdiantz A, Kumar MA, Slack E, Soliman HA, MacIntyre I (1964) Thyroid origin of calcitonin. Nature 202:1303–1305PubMedCrossRefGoogle Scholar
  29. Fraser DR (1980) Regulation of the metabolism of vitamin D. Physiol Rev 60:551–607PubMedGoogle Scholar
  30. Freake HC, MacIntyre I (1982) Specific binding of 1,25-dihydroxycholecalciferol in human medullary thyroid carcinoma. Biochem J 206:181–184PubMedGoogle Scholar
  31. Friedman J, Raisz LG (1965) Thyrocalcitonin inhibitor of bone resorption in tissue culture. Science 150:1465–1467PubMedCrossRefGoogle Scholar
  32. Galan Galan F, Perez Cano R, Rodriguez R et al. (1985) Deficit de calcitonia en la osteoporosis posmenopausica. Med Clin (Barc) 85:221Google Scholar
  33. Galante L, Colston KW, MacAuley SJ, MacIntyre I (1972) Effect of calcitonin on vitamin D metabolism. Nature 238:271–273PubMedCrossRefGoogle Scholar
  34. Garabedian M, Holick MF, DeLuca HF, Boyle IT (1972) Control of 25-hydroxycholecal-ciferol metabolism by parathyroid glands. Proc Natl Acad Sci USA 69:1673–1676PubMedCrossRefGoogle Scholar
  35. Girgis SI, Macdonald DWR, Stevenson JC, Bevis PJR, Lynch C, Wimalawansa SJ, Self CH, Morris HR, MacIntyre I (1985) Calcitonin gene-related peptide: potent vasodilator and major product of calcitonin gene. Lancet 2:14–16PubMedCrossRefGoogle Scholar
  36. Goldsmith RS, Furszyfer J, Johnson WJ, Fournier AE, Sizemore GW, Arnaud CD (1973) Etiology of hyperparathyroidism and bone disease during chronic hemodialysis. III. Evaluation of parathyroid suppressibility. J Clin Invest 52:173–180PubMedCrossRefGoogle Scholar
  37. Goltzman D, Mitchell J (1985) Interaction of calcitonin and calcitonin gene-related peptide at receptor sites in target tissues. Science 227:1343–1345PubMedCrossRefGoogle Scholar
  38. Habener JF, Rosenblatt M, Potts JT Jr (1984) Parathyroid hormone: biochemical aspects of biosynthesis, secretion, action and metabolism. Physiol Rev 64:985–1053PubMedGoogle Scholar
  39. Hausslet MR, Bayling DJ, Hughes MR, Brumbaugh PF, Wergedal JE, Shen FH, Nielsen RL, Counts SJ, Bursac KM, McCain TA (1976) The assay of 1α,25-dihydroxyvitamin D3: physiologic and pathologic modulation of circulating hormone levels. Clin Endocrinol (Oxf) 5:151S–165SCrossRefGoogle Scholar
  40. Heinrich G, Kronenberg HM, Potts JT Jr, Habener JF (1984) Gene encoding parathyroid hormone. Nucleotide sequence of the rat gene and deduced aminoacid sequence of rat preproparathyroid hormone. J Biol Chem 259:3320–3329PubMedGoogle Scholar
  41. Hillyard CJ, Stevenson JC, MacIntyre I (1978) Relative deficiency of plasma-calcitonin in normal women. Lancet 1:961–962PubMedCrossRefGoogle Scholar
  42. Hillyard CJ, Myers C, Abeyasekera G, Stevenson JC, Craig RK, MacIntyre I (1983) Katacalcin: a new plasma calcium-lowering hormone. Lancet 1:846–848PubMedCrossRefGoogle Scholar
  43. Hirsch PF, Gauthier GF, Munson PL (1963) Thyroid hypocalcaemic principle and recurrent laryngeal nerve injury as factors affecting the response to parathyroidectomy in rats. Endocrinology 73:244–252PubMedCrossRefGoogle Scholar
  44. Hoppener JWM, Steenbergh PH, Bakker E, Pearson PL, Geurts van Kessel AHM, Jansz HS, Lipps CJM (1984) Localization of the polymorphic human calcitonin gene on chromosome 11. Hum Genet 66:309–312PubMedCrossRefGoogle Scholar
  45. Hoppener JWM, Steenbergh PH, Geurts van Kessel AHM, Baylin SB, Nelkin BD, Jansz HS, Lips CJM (1985) The second human calcitonin/CGRP gene is located on chromosome 11. Hum Genet 70:259–263PubMedCrossRefGoogle Scholar
  46. Horiuchi N, Suda T, Sasaki S, Takahashi H, Shimazawa E, Ogata E (1976) Absence of regulatory effects of 1,25-dihydroxyvitamin D3 on 25-hydroxyvitamin D metabolism in rats constantly infused with parathyroid hormone. Biochem Biophys Res Commun 73:869–875PubMedCrossRefGoogle Scholar
  47. Kaminsky NI, Broadus AE, Hardman JG, Jones DJ Jr, Ball JH, Sutherland EW, Liddle GW (1970) Effects of parathyroid hormone plasma and urinary adenosine 3′,5′-monophosphate in man. J Clin Invest 49:2387–2395PubMedCrossRefGoogle Scholar
  48. Kawashima H, Torikai S, Kurokawa K (1981) Calcitonin selectively stimulates 25-hydroxyvitamin D3-1-hydroxylase in proximal straight tubule of rat kidney. Nature 291:327–319PubMedCrossRefGoogle Scholar
  49. Keutman HT, Sauer RM, Hendy GN, O’Riordan JLH, Potts JT Jr (1978) Complete amino acid sequence of human parathyroid hormone. Biochemistry 17:5723–5729CrossRefGoogle Scholar
  50. Kittur SD, Hoppener JWM, Antonaratis SE, Daniels JDJ, Meyers DA, Maestri NE, Jansen M, Kormeluk RG, Neltin BD, Kazazian HH (1985) Linkage map of the short arm of human chromosome 11: location of the genes for catalase, calcitonin and insulin-like growth factor II. Proc Natl Acad Sci USA 82:5064–5067PubMedCrossRefGoogle Scholar
  51. Kumar MA, Foster GV, MacIntyre I (1963) Further evidence for calcitonin, a rapid-acting hormone which lowers plasma calcium. Lancet 2:480–482PubMedCrossRefGoogle Scholar
  52. Lafeber F, Hermann-Erlee MPM, van der Meer JM, Flick G, Verbost P, Wendelaar Bonga SE (1984) Effects of products released by trout corpuscles of Stannius on calcium mobilization and cAMP formation of mouse calvaria in vitro and on plasma calcium in eels. Calcif Tissue Int [Suppl 2] 3:50Google Scholar
  53. Larkins RG, MacAuley SJ, Colston KW, Evans IMA, Galante LS, MacIntyre I (1973) Regulation of vitamin D metabolism without parathyroid hormone. Lancet 2:289–291PubMedCrossRefGoogle Scholar
  54. Lee Y, Kawai Y, Shiosaka S, Takami K, Kiyama H, Hillyard CJ, Girgis S, MacIntyre I, Emson PC, Tohyama M (1985) Coexistence of calcitonin gene-related peptide and substance P-like peptide in single cells of the trigeminal ganglion of the rat: immunohistochemical analysis. Brain Res 330:194–196PubMedCrossRefGoogle Scholar
  55. Lopez E, Tisserand-Jochem EM, Eyquem A, Milet C, Hillyard C, Lallier F, Vidal B, MacIntyre I (1984 a) Immunocytochemical detection in eel corpuscles of Stannius of a mammalian parathyroid-like hormone. Gen Comp Endocrinol 53:28–36PubMedCrossRefGoogle Scholar
  56. Lopez E, Tisserand-Jochem EM, Vidal B, Milet C, Lallier F, MacIntyre I (1984 b) Les corpuscles de Stannius sont-ils les glandes parathyroides des poissons téléostéens? Arguments ultrastructuraux, cytologiques et immunocytochimiques. CR Seances Acad Sci [III] 298:359–364Google Scholar
  57. Lwowski ES (1978) The corpuscles of Stannius and calcified tissues in the eel, Anguilla rostrata L. Comp Biochem Physiol 59A:183–187CrossRefGoogle Scholar
  58. Ma SWY, Copp DH (1978) Purification, properties and action of a glycopeptide from the corpuscles of Stannius which affects calcium metabolism in the teleost. In: Gaillard PJ, Boer HH (eds) Comparative endocrinology. Elsevier/North Holland, Amsterdam, pp 283–286Google Scholar
  59. MacIntyre I (1984) The calcitonin gene peptide family and the central nervous system. In: Labrie F, Proulx L (eds) Proceedings of the 7th International Congress of Endocrinology, Quebec, Canada, July 1984. Excerpta Medica, Amsterdam, pp 930–933Google Scholar
  60. MacIntyre I (1987) Calcitonin gene peptides. In: De Groot L (ed) Endocrinology, 2nd edn. Grune and Stratton, OrlandoGoogle Scholar
  61. MacIntyre I, Colston KW, Szelke M, Spanos E (1978) A survey of hormonal factors that control calcium metabolism. In: Scarpa A, Carafoli E (eds) Calcium transport and cell function. Ann NY Acad Sci 307:345–355Google Scholar
  62. MacIntyre I, Arnett TR, Brown DJ, Galan Galan F, Girgis SI, Rogers RM, Spanos E, Stevenson JC, Bone Q (1979) The interrelation of the calcium regulating hormones: some recent findings. In: MacIntyre I, Szelke M (eds) Molecular endocrinology. Elsevier/North Holland, Amsterdam, pp 193–201Google Scholar
  63. MacIntyre I, Milet C, Arnett TR, Coghlan JP, Hillyard CJ, Girgis S, Martelly E, Niall HD, Lopez E (1981) The eel corpuscles of Stannius secrete a molecule resembling mammalian parathyroid hormone (abstr 165). 63rd Annual Meeting of the Endocrine Society USA (1981)Google Scholar
  64. MacIntyre I, Hillyard CJ, Murphy PK, Reynolds JJ, Gaines Das RE, Craig RK (1982) A second plasma calcium lowering peptide from the human calcitonin precursor. Nature 300:460–462PubMedCrossRefGoogle Scholar
  65. MacIntyre I, Hillyard CJ, Reynolds JJ, Gaines Das RE, Craig RK (1984) A second plasma calcium lowering peptide from the human calcitonin precursor: a re-evaluation. Nature 308:84PubMedGoogle Scholar
  66. MacIntyre I, Alerizaki M, Bevis PJR, Zaidi M (1987) Calcitonin and peptides from the calcitonin gene. Clin Orthop and Rel Res 217:45–54Google Scholar
  67. McEwan J, Chierchia S, Davies G, Stevenson JC, Brown M, Maseri A, MacIntyre I (1985) Coronary vasodilatation by calcitonin gene-related peptide. Br Heart J 54:643–645Google Scholar
  68. McSheehy PMJ, Chambers TJ (1986 a) Osteoblastic cells mediate osteoclastic responsiveness to PTH. Endocrinology 118:824–827PubMedCrossRefGoogle Scholar
  69. McSheehy PMJ, Chambers TJ (1986 b) Osteoblast-like cells in the presence of parathyroid hormone release soluble factor that stimulates osteoblastic bone resorption. Endocrinology 119 (in press)Google Scholar
  70. Milet C (1986) PhD Dissertation, University of Paris (in press)Google Scholar
  71. Milet C, Lopez E, Chartier MM, Martelly E, Lallier F, Vidal B (1979 a) A new calcium regulating hormone from the corpuscles of Stannius. In: MacIntyre I, Szelke M (eds) Molecular endocrinology. Elsevier/North Holland, Amsterdam, pp 341–348Google Scholar
  72. Milet C, Peignoux-Deville J, Martelly E (1979 b) Gill calcium fluxes in the eel, Anguilla anguilla L. Effects of Stannius corpuscles and ultimobranchial body. Comp Biochem Physiol 63A:63–70CrossRefGoogle Scholar
  73. Milet C, Hillyard CJ, Martelly E, Girgis S, MacIntyre I, Lopez E (1980) Similitudes structurales entre l’hormone hypocalcémiante des corpuscles de Stannius (PCS) de l’anguille (Anguilla anguilla L.) et l’hormone parathyroidienne mammalienne. CR Seances Acad Sci [III] 291:977–980Google Scholar
  74. Milhaud G, Perault A-M, Moukhtar MA (1965) Etude du mécanisme de l’action hypocalcémiante de la thyrocalcitonine. CR Seances Acad Sci [III] 261:813–816Google Scholar
  75. Morimoto S, Tsuji M, Okada Y, Onishi T, Kumahara Y (1980) The effect of oestrogens on human calcitonin secretion after calcium infusion in elderly female subjects. Clin Endocrinol (Oxf) 13:135–143CrossRefGoogle Scholar
  76. Morris HR, Panico M, Etienne T, Tippins J, Girgis SI, MacIntyre I (1984) Isolation and characterisation of human calcitonin gene-related peptide. Nature 308:746–748PubMedCrossRefGoogle Scholar
  77. Nagant de Deuxchaisnes C, Rombouts-Lindemans C, Huaux JP, Devogelaer JP, Malghem J, Maldague B (1979) Roentgenologic evaluation of the action of the diphosphonate EHDP and of combined therapy (EHDP and calcitonin) in Paget’s disease of bone. In: MacIntyre I, Szelke M (eds) Molecular endocrinology. Elsevier/North Holland, Amsterdam, pp 405–433Google Scholar
  78. Parsons JA (1976) Parathyroid physiology and the skeleton. In: Bourne GH (ed) The biochemistry and physiology of bone. Academic, New York, pp 159–225Google Scholar
  79. Parsons JA, Zanelli JM (1980) Physiological role of the parathyroid glands. In: Kuhlencordt F, Bartelheimer H (eds) Klinische Osteologie. Springer, Berlin Heidelberg New York, pp 135–172 (Handbuch der inneren Medizin, vol 6/1)Google Scholar
  80. Robinson CJ, Martin TJ, Matthews EW, MacIntyre I (1967) Mode of action of thyrocalcitonin. J Endocrinol 39:71–79PubMedCrossRefGoogle Scholar
  81. Rosenblatt M, Beaudette NV, Fasman GD (1980) Conformational studies of the synthetic precursor-specific region of pre-proparathyroid hormone. Proc Natl Acad Sci USA 77:3983–3987PubMedCrossRefGoogle Scholar
  82. Rosenfeld MG, Lin CR, Amara SG, Stolarsky L, Roos BA, Ong ES, Evans RM (1982) Calcitonin mRNA polymorphism: peptide switching associated with alternative RNA splicing events. Proc Natl Acad Sci USA 79:1717–1721PubMedCrossRefGoogle Scholar
  83. Rosenfeld MG, Mermod J-J, Amara SG, Swanson LW, Sawchenko PE, Rivier J, Vale WW, Evans RM (1983) Production of a novel neuropeptide encoded by the calcitonin gene via tissue-specific RNA processing. Nature 304:129–135PubMedCrossRefGoogle Scholar
  84. Stannius FH (1839) Ueber Nebennieren bei Knochenfischen. Arch Anat Physiol 91–101Google Scholar
  85. Steenbergh PH, Hoppener JWM, Zandberg J, Lips CJM, Jansz HS (1985) A second human calcitonin/CGRP gene. FEBS Lett 183:403–407PubMedCrossRefGoogle Scholar
  86. Stevenson JC, Hillyard CJ, MacIntyre I, Cooper H, Whitehead MI (1979) Physiological role for calcitonin: protection for the maternal skeleton. Lancet 2:769–770PubMedCrossRefGoogle Scholar
  87. Stevenson JC, Abeyasekera G, Hillyard CJ, Phang KG, MacIntyre I, Campbell S, Townsend PT, Young O, Whitehead MI (1981) Calcitonin and the calcium-regulating hormones in postmenopausal women: effect of oestrogens. Lancet 1:693–695PubMedCrossRefGoogle Scholar
  88. Stevenson JC, MacIntyre I, Whitehead MI (1982) Impaired calcitonin secretion after premature menopause. Calcif Tissue Int [Suppl 1] 34:821Google Scholar
  89. Stevenson JC, Abeyasekera G, Hillyard CJ, Phang KG, MacIntyre I, Campbell S, Lane E, Townsend PT, Young O, Whitehead MI (1983) Regulation of calcium-regulating hormones by exogenous sex steroids in early postmenopause. Eur J Clin Invest 13:481–487PubMedCrossRefGoogle Scholar
  90. Struthers AD, Brown MJ, Macdonald DWR, Beacham JL, Stevenson JC, Morris HR, MacIntyre I (1985) Human CGRP: the most potent endogenous vasodilator in man. Clin Sci 70:389–393Google Scholar
  91. Suda T, Abe E, Miyaura C et al. (1983) Does vitamin D have a specific role in cell growth and differentiation? In: Cohn DV, Fujita T, Potts JT Jr, Talmage RV (eds) Endocrine control of bone and calcium metabolism, vol 8A. Excerpta Medica, Amsterdam, pp 308–315Google Scholar
  92. Taggert HMc, Chesnut CH, Ivey JL, Baylink DJ, Sisom K, Huber MB, Roos BA (1982) Deficient calcitonin response to calcium stimulation in postmenopausal osteoporosis. Lancet 1:475–478CrossRefGoogle Scholar
  93. Tippins JR, Morris HR, Panico M, Etienne T, Bevis P, Girgis S, MacIntyre I, Azria M, Attinger M (1984) The myotropic and plasma-calcium modulating effects of calcitonin gene-related peptide (CGRP). Neuropeptides 4:425–434PubMedCrossRefGoogle Scholar
  94. Torring O, Bucht E, Sjöberg HE (1984) Can a relative calcitonin deficiency contribute to the development of postmenopausal osteoporosis? In: Christiansen C, Arnaud CD, Nordin BEC, Parfitt AM, Peck WA, Riggs BL (eds) Osteoporosis. Glostrup Hospital, Glostrup, pp 393–395Google Scholar
  95. Tschopp FA, Tobler PH, Fischer JA (1984) Calcitonin gene-related peptide in the human thyroid pituitary and brain. Mol Cell Endocrinol 36:53–57PubMedCrossRefGoogle Scholar
  96. Tschopp FA, Henke H, Petermann JB, Tobler TH, Janzer R, Hokfelt T, Lundberg JM, Cuells C, Fischer JA (1985) Calcitonin gene related peptide and its binding site in the human central nervous system and pituitary. Proc Natl Acad Sci USA 82:248–252PubMedCrossRefGoogle Scholar
  97. Wanaka A, Matsuyama T, Yoneda S, Kimura K, Kamada T, MacIntyre I, Emson PC, Tohyama M (1987) Origins and distribution of calcitonin gene-related peptide-containing nerves in the wall of the cerebral arteries of the guinea pig with special reference to the coexistence with substance P. Brain Res (in press)Google Scholar
  98. Zaidi M, Bevis PJR, Abeyasekera G, Girgis SI, MacIntyre I (1985 a) Studies on circulating calcitonin gene-related peptide in the rat. J Endocrinol 107:43Google Scholar
  99. Zaidi M, Bevis PJR, Girgis SI, Lynch C, Stevenson JC, MacIntyre I (1985 b) Circulating CGRP comes from the perivascular nerves. Eur J Pharmacol 117:283–284PubMedCrossRefGoogle Scholar
  100. Zaidi M, Bevis PJR, Abeyasekera G, Girgis SI, Wimalawansa SJ, Morris HR, MacIntyre I (1986 a) The origin of calcitonin gene-related peptide in the rat. J Endocrinol 110:185–190PubMedCrossRefGoogle Scholar
  101. Zaidi M, Bevis PJR, Diez Guerra J, Lynch C, Wimalawansa SJ, Emson PC, MacIntyre I (1986 b) Circulation of neurally derived calcitonin gene related peptide (abstr). Neuroendocrinology 74 (Special Issue)Google Scholar
  102. Zaidi M, Bevis PJR, MacIntyre I (1986 c) The dual origin of plasma calcitonin gene related peptide (abstr). 68th Annual Meeting of the Endocrine SocietyGoogle Scholar
  103. Zaidi M, Bevis PJR, Lynch C, McSheehy PMJ, Chambers TJ, MacIntyre I (1986d) The calcitonin-like effect of α and ß human CGRP is mediated via direct osteoclastic inhibition. J Bone Min Res 1:357Google Scholar
  104. Zaidi M, Fuller K, Bevis PJR, Gaines Das RE, Chambers TJ, MacIntyre I (1987 a) Calcitonin gene related peptide inhibits osteoclastic bone resorption: a comparative study. Calcif Tissue Int 40:149–154PubMedCrossRefGoogle Scholar
  105. Zaidi M, Chambers TJ, Gaines Das RE, Morris HR, MacIntyre I (1987 b) A direct effect of human calcitonin gene related peptide on isolated osteoclasts. J Endocrinol 115 (in press)Google Scholar

References added in proof

  1. Alevizaki M, Shiraishi A, Rassool FV, Ferrier GJM, MacIntyre I, Legon S (1986) The calcitonin-like sequence of the-CGRP gene. FEBS Lett 206:47–41PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • I. MacIntyre
  • M. Zaidi
  • C. Milet
  • P. J. R. Bevis

There are no affiliations available

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