Hormonal Control of Extracellular Calcium

  • I. MacIntyre
  • M. Zaidi
  • C. Milet
  • P. J. R. Bevis
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 83)


Despite wide differences in calcium intake, plasma calcium is maintained with remarkable constancy. Approximately half of total plasma calcium is ionised and the remainder is largely bound to plasma albumin. Extracellular calcium concentration is more than 1000-fold greater than the critical intracellular concentration; a major change in the former would almost certainly be followed by gross disturbances in cellular metabolism, eventually leading to death. To prevent this, a set of interlocking hormonal mechanisms have evolved in vertebrates. These have been reviewed here with particular reference to the major clinical consequences of their disturbance and therapeutic approaches used for their correction.


Plasma Calcium Human Calcitonin Plasma Calcitonin Calcitonin Secretion Carboxy Terminal Fragment 
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References added in proof

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© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • I. MacIntyre
  • M. Zaidi
  • C. Milet
  • P. J. R. Bevis

There are no affiliations available

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