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Calcium and Synaptic Function

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Calcium in Drug Actions

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 83))

Abstract

Calcium ions play many important roles in the function of nerve cells. Calcium’s involvement in neurotransmitter release is one of its key roles, and was one of the first to be recognized. Early observations demonstrated that extracellular Ca was required for neurotransmitter release (Harvey and Macintosh 1940). Subsequent studies established that transmitter release was evoked by Ca entry and a rise in [Ca2+]i, the intracellular free Ca concentration. This sequence of events accounted for the external Ca dependence (Katz 1969; Baker 1972; Llinas et al. 1981; Drapeau and Blaustein 1983 a, b). Moreover, the modulation of synaptic transmission, and related fundamental aspects of transmitter release associated with memory and learning, are all profoundly influenced by Ca.

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Authors
  1. M. P. Blaustein
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Editors and Affiliations

  1. Department of Physiology King’s College, University of London, Strand, London, WC2R 2LS, Great Britain

    Peter F. Baker (Professor Sc. D., F.R.S.) (Professor Sc. D., F.R.S.)

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Dedicated to the memory of my student, friend, and colleague, Daniel A. Nachshen, who so carefully elucidated the properties of calcium channels in nerve terminals.

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© 1988 Springer-Verlag Berlin Heidelberg

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Blaustein, M.P. (1988). Calcium and Synaptic Function. In: Baker, P.F. (eds) Calcium in Drug Actions. Handbook of Experimental Pharmacology, vol 83. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71806-9_15

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  • DOI: https://doi.org/10.1007/978-3-642-71806-9_15

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