Abstract
The regulation of cerebral blood flow (CBF) is mainly attributed to myogenic mechanisms and metabolic influences. The myogenic reaction to intraluminal pressure is considered to provide cerebral autoregu-lation (8), whereas pCO2 tension and tissue lactate level are assumed to regulate regional cerebral blood flow (rCBF) according to metabolic requirements (7, 10). The means by which regulation of local cerebral microcirculation (1CBF) occurs, however, remains unknown (10).
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Astrup J, Symon L, Branston NM, Lassen NA (1977) Cortical evoked potential and extracellular K+ and H+ at critical levels of brain ischemia. Stroke 8:51–57
Heller V (1986) Sauerstoffgehalt, Sauerstoffverbrauch und lokale Durchblutung beim experimentellen Hirnödem: Veränderungen durch Pentobarbital, Dexamethason und Nimodipine. Thesis, University of Würzburg, Germany
Heller V, Poch B, Gaab MR, Sold M, Heissler HE (1984) O2 availability and O2 metabolism in cold induced brain edema. In: Go KG, Baethmann A (eds) Recent progress in the study and therapy of brain edema. Plenum, New York London, pp 397–405
Herrmann F, Gaab MR, Pflughaupt KW, Gruss P (1981) Medikamentöse Therapie beim experimentellen Hirnödem. Neurochirurgia 24:39–46
Kessler M, Höper J (1985) Signaloxidasen, Signalketten in Leber, Niere und Myocard. In: Kinne R, Acker H, Leniger-Follert E (Hrsg) Festschrift aus Anlaß der Emeritierung von D.W. Lübbers. Max-Planck-Institut für Systemphysiologie, Dortmund, pp 121–155
Kessler M, Höper J, Krumme BA (1976) Tissue perfusion and cellular function. Anaethesiol 45:186–199
Kuschinsky W, Wahl M (1978) Local chemical and neurogenic regulation of cerebral vascular resistance. Physiol Rev 58:656–689
Lassen NA (1974) Control of cerebral circulation in health and disease. Circ Res 34:749–760
Lübbers DW (1968) The oxygen pressure field of the brain and its significance for the normal and critical oxygen supply of the brain. In: Lubbers DW, Luft UC, Thews G, Witzleben E (eds) Oxygen transport in blood and tissue. Thieme, Stuttgart, pp 125–139
McHenry LC Jr (1978) Cerebral circulation and stroke. W.H. Green, St. Louis
Pappius HM, Wolfe LS (1984) Effect of drugs on local cerebral glucose utilization in traumatized brain: mechanisms of action of steroids revisited. In: Go KG, Baethmann A (eds) Recent progress in the study and therapy of brain edema. Plenum, New York London, pp 11–26
Poch B (1986) Sauerstoffspannung, Sauerstoffverbrauch und Mikrozirkulation der normalen und traumatisierten Gehirnrinde. Thesis, University of Würzburg, Germany
Poch B, Heller V, Gaab MR, Sold M, Heissler HE (1983) Cerebral oxygen tension and microcirculation in barbiturate treatment. An experimental investigation. In: Jensen H-P, Brock M, Klinger M (eds) Advances in neurosurgery, vol 11. Springer, Berlin Heidelberg New York, pp 324–330
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© 1987 Springer-Verlag Berlin Heidelberg
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Gaab, M.R., Poch, B., Heller, V. (1987). Oxygen Metabolism and Microcirculation of the Brain in Various Conditions: Experimental Investigations. In: Wüllenweber, R., Klinger, M., Brock, M. (eds) Regulation of Cerebral Blood Flow and Metabolism Neurosurgical Treatment of Epilepsy Rehabilitation in Neurosurgery. Advances in Neurosurgery, vol 15. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71793-2_6
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DOI: https://doi.org/10.1007/978-3-642-71793-2_6
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