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Chronic Cerebellar Stimulation in the Treatment of Epilepsy

  • B. Klun
  • V. Stojanović
  • P. Strojnik
  • U. Stanič
  • L. Vodovnik
  • S. Žirovnik
Conference paper
Part of the Advances in Neurosurgery book series (NEURO, volume 15)

Abstract

In the early to mid 19 70s Cooper et al. (3) put to practical use the theoretical concepts of Julien (4), who ascertained the inhibitory action of the Purkinje cells on the motor cortex, the classical work of Moruzzi (5) about the inhibition of spasticity by the same cells, and the work of Dow et al. (2), who showed that removal of the cerebellar cortex intensifies epileptic activity and demonstrated the existence of an inhibitory mechanism in the reticular structures of the cerebellum. Cooper et al. (3) presented a rather small series with promising results. However, the method was subjected to considerable criticism. The main arguments against it included potential damage to the nervous substance and the number of complications connected with the surgical procedure, such as CSF leakage, breakage of the leads, and frequent mechanical failures.

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References

  1. 1.
    Dow RS (1974) Some novel concepts of cerebellar physiology. Mt. Sinai J Med NY 41:103–119Google Scholar
  2. 2.
    Dow RS, Fernandez-Guardiola A, Manni E (1962) The influence of the cerebellum on experimental epilepsy. Electroencephalogr Clin Neuro-physiol 14:383–398CrossRefGoogle Scholar
  3. 3.
    Cooper IS, Amin I, Gilman S (1974) The effect of chronic stimulation of cerebellar cortex on epilepsy in man. In: Cooper IS, Riklan M, Snider RS (eds) The cerebellum, epilepsy and behaviour. Plenum Press, New YorkCrossRefGoogle Scholar
  4. 4.
    Julien RM (1974) Experimental epilepsy: cerebro-cerebellar interaction and epileptic drugs. In: Cooper IS, Riklan M, Snider RS (eds) The cerebellum, epilepsy and behaviour. Plenum Press, New YorkGoogle Scholar
  5. 5.
    Moruzzi G (1956) Effects at different frequencies of cerebellar stimulation upon postural tonus and myotatic reflexes. Electroencephalogr Clin Neurophysiol 2:463–469Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • B. Klun
    • 1
  • V. Stojanović
    • 1
  • P. Strojnik
    • 1
  • U. Stanič
    • 1
  • L. Vodovnik
    • 1
  • S. Žirovnik
    • 1
  1. 1.Department of NeurosurgeryUniversity Medical CenterLjubljanaYugoslavia

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