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Receptor and Postreceptor Changes During Lymphocyte Aging

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Blood Cells, Rheology, and Aging

  • 131 Accesses

Abstract

The ability of hormones, neurotransmitters, drugs, and other similar agents to stimulate various cellular physiologic and biochemical responses becomes altered during aging in many cases (Roth and Hess 1982). Generally such changes are in the negative direction: a decreased magnitude of response, a reduced sensitivity to the stimulatory agent, a longer time to respond, etc. (Roth and Hess 1982). The lymphocyte serves as a useful system for examining such age-related alterations for a number of reasons (Adler and Nordin 1981; Kay and Makinodan 1981):

  1. 1.

    This cell type can be obtained by relatively noninvasive procedures.

  2. 2.

    Lymphocytes are responsive to and possess receptors for many agents.

  3. 3.

    The mechanisms of action of these agents have been reasonably well characterized and appear to be similar in lymphocytes and other less accessible tissues.

  4. 4.

    Age changes in immunologic responsiveness, a primary physiologic dysfunction of senescence, can be at least partially localized in specific lymphocyte populations.

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Authors
  1. G. S. Roth
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Editor information

Editors and Affiliations

  1. Instituts für Gerontologie, Universität Erlangen-Nürnberg, Flurstraße 17, D-8500, Nürnberg, Germany

    Dieter Platt (Direktor) (Direktor)

  2. 2. Medizinischen Klinik, Klinikum Nürnberg, Flurstraße 17, D-8500, Nürnberg, Germany

    Dieter Platt (Direktor) (Direktor)

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© 1988 Springer-Verlag Berlin Heidelberg

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Roth, G.S. (1988). Receptor and Postreceptor Changes During Lymphocyte Aging. In: Platt, D. (eds) Blood Cells, Rheology, and Aging. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71790-1_15

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  • DOI: https://doi.org/10.1007/978-3-642-71790-1_15

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-71792-5

  • Online ISBN: 978-3-642-71790-1

  • eBook Packages: Springer Book Archive

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