Comparisons of Regional Topography and Flow Reactivity in Cerebral Ischemic Boundary Zones

  • A. J. Strong
  • S. A. Miller
  • G. S. Venables
Conference paper

Abstract

Although the term “penumbra” has been used since 1977 [1] to describe an ischemic boundary zone characterized by suppression of electrophysiological function with complete or near-complete preservation of extracellular potassium homeostasis, there is continued uncertainty regarding its nature and extent, and hence its significance in relation to the management of cerebral ischemia as it presents in man.

Keywords

Depression Ischemia Platinum Hexagonal NADH 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Astrup J, Symon L, Branston NM, Lassen NA (1977) Cortical evoked potential and extracellular K + and H + at critical levels of brain ischaemia. Stroke 8: 51–57PubMedCrossRefGoogle Scholar
  2. 2.
    Pasztor E, Symon L, Dorsch NWC, Branston NM (1973) The hydrogen clearance method in the assessment of blood flow in cortex, white matter, and deep nuclei of baboons. Stroke 4: 556–567PubMedCrossRefGoogle Scholar
  3. 3.
    Strong AJ, Venables GS, Gibson G (1983) The cortical ischaemic penumbra associated with occlusion of the middle cerebral artery in the cat: 1. Topography in changes of blood flow, potassium ion activity, and EEG. J Cereb Blood Flow and Metabol 3: 86–96CrossRefGoogle Scholar
  4. 4.
    Symon L, Pasztor E, Branston NM (1974) The distribution and density of reduced cerebral blood flow following acute middle cerebral artery occlusion. Stroke 5: 355–364PubMedCrossRefGoogle Scholar
  5. 5.
    Tyson GW, Teasdale GM, Graham DI, McCulloch J (1984) Focal cerebral ischaemia in the rat: topography of hemodynamic and histopathological changes. Ann Neurol 15: 559–567PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • A. J. Strong
    • 1
  • S. A. Miller
    • 1
  • G. S. Venables
    • 1
  1. 1.Departments of Surgery (Neurosurgery) and Neurology, (GSV)University of Newcastle-Upon-TyneNewcastleUK

Personalised recommendations