Arachidonic Acid Metabolism in Cerebral Ischemia

  • L. C. Pettigrew
  • E. R. Hall
  • J. C. Grotta
  • K. K. Wu


Cerebral ischemia and infarction result from impaired perfusion of brain tissue. Cellular homeostasis is disrupted by a variety of factors, one of which is deacylation of phospholipid membranes resulting in generation of arachidonic acid (AA) and its proaggregatory and vasoconstrictive metabolites, prostaglandin H2 (PGH2) and thromboxane A2 (TXA2). Our interest in AA metabolism in cerebral ischemia has developed from our studies of platelet-vessel wall interactions in the deendothelialized rabbit aorta. We have used this model, along with in vitro studies of platelet aggregation, to investigate pharmacological inhibition of AA metabolism. This paper will review our earlier work and give the results of experiments using 1-benzylimidazole (1-BI), a selective inhibitor of thromboxane synthase, in a rat model of transient forebrain ischemia.


Platelet Aggregation Cerebral Ischemia Thrombotic Thrombocytopenic Purpura Arachidonic Acid Metabolism Bilateral Common Carotid Artery Occlusion 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • L. C. Pettigrew
    • 1
  • E. R. Hall
    • 1
  • J. C. Grotta
    • 1
  • K. K. Wu
    • 1
  1. 1.Department of NeurologyUniversity of Texas, Medical SchoolHoustonUSA

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