Abstract
It is now well appreciated that blood viscosity plays an important role in the pathophysiology of cerebral ischemia. Recent studies have increasingly focused on the effectiveness of the hemorheological approach to the treatment of cerebrovascular diseases. While numerous studies have been undertaken to measure changes in cerebral blood flow (CBF) after stroke, little attention has been paid to the role of cerebral blood volume (CBV) and cerebral hematocrit (Hct) in the pathophysiology of acute cerebral ischemia. Using PET, Gibbs et al. [3] and Powers et al. [7] have shown that dissociation between regional CBF and CBV occurs following the occlusion of large cerebral arteries. These authors also suggested that cerebral mean transit time (MTT) derived from the ratio between CBF and CBV might serve as a sensitive parameter to measure circulatory reserve in the ischemic tissue.
This is a preview of subscription content, log in via an institution to check access.
Preview
Unable to display preview. Download preview PDF.
References
Barbee JH, Coke1et GR (1971) The Fahraeus effect. Microvasc Res 3: 6–16
Fahraeus R (1929) The suspension stability of fluid. Physiol Rev 9: 241–274
Gibbs JM, Wise RJS, Leenders KL, Jones T (1984) Evaluation of cerebral perfusion reserve in patients with carotid-artery occlusion. Lancet 2: 310–314
Lammertsma AA, Brooks DJ, Beaney RP, Turton DR, Kensett MJ, Heather JD, Marshall J, Jones T (1984) In vivo measurement of regional cerebral hematocrit using positron emission tomography. J Cereb Blood Flow Metabol 4: 317–322
Larsen OA, Lassen NA (1964) Cerebral hematocrit in normal man. J Appl Physiol 19: 571–574
Oldendorf WH, Kitano M, Shimizu S, Oldendorf SZ (1965) Hematocrit of human cerebral blood pool. Circ Res 17: 532–539
Powers WJ, Grubb RL, Raichle ME (1984) Physiological response to focal cerebral ischemia in humans. Ann Neurol 16: 546–552
Rosenblum WI (1972) Erythrocyte velocity and fluorescein transit time through the cerebral microcirculation in experimental polycythemia. Exp Neurol 31: 126–131
Sakai F, Nakazawa K, Tazaki Y, Ishii K, Hino H, Igarashi H, Kanda T (1985) Regional cerebral blood volume and hematocrit measured in normal human volunteers by singlephoton emission computed tomography. J Cereb Blood Flow Metabol 5: 207–213
Tomita M, Gotoh F, Amano T, Tanahashi N, Tanaka K (1980) “Low perfusion hyperemia” following middle cerebral artery occlusion in cats of different age groups. Stroke 11: 629–636
Tomita M, Gotoh F, Amano T, Tanahashi N, Kobari M, Shinohara T, Mihara B (1983) Transfer function through regional cerebral cortex evaluated by a photoelectric method. Am J Physiol 245:H385–H398
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1987 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Sakai, F., Tazaki, Y. (1987). Regional Cerebral Blood Flow, Volume, and Hematocrit Measured by Single Photon Emission Computed Tomography. In: Hartmann, A., Kuschinsky, W. (eds) Cerebral Ischemia and Hemorheology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71787-1_21
Download citation
DOI: https://doi.org/10.1007/978-3-642-71787-1_21
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-71789-5
Online ISBN: 978-3-642-71787-1
eBook Packages: Springer Book Archive