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Glaucoma Update III pp 225–235Cite as

Pharmacologic Alteration of Aqueous Humor Dynamics in Normotensive and Glaucomatous Monkey Eyes

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Abstract

The results of pharmacologic testing in clinical trials, with drugs that successfully lower intraocular pressure (IOP) in experimental animals, have often been disappointing. The variability in response to drugs amongst the species may be due to differences in anatomy [1]; drug penetration; and/or receptor quantity, quality, location, or regulation [2]. A reliable and readily available model that closely mimics human glaucoma is needed to determine the efficacy and mechanism of action of potential ocular hypotensive agents prior to embarking upon clinical trials. The normal monkey eye is similar to the human eye with respect to iridocorneal angle anatomy, physiology, and response to ocular hypotensive drugs. The argon laser-induced glaucomatous monkey eye may be a satisfactory model to evaluate the potential efficacy of experimental drugs.

Supported in part by grants EY01867, EY03651, EY05852, and EY05841 from the National Eye Institute, Bethesda, Maryland; an unrestricted grant from Research to Prevent Blindness, Inc., New York, New York; a grant-in-aid from the National Society to Prevent Blindness, New York, New York; and a grant from the Heed Ophthalmic Foundation, Chicago, Illinois.

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Authors and Affiliations

  1. New York, USA

    S. M. Podos, C. B. Camras, J. B. Serle & P.-Y. Lee

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  1. S. M. Podos
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  2. C. B. Camras
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  3. J. B. Serle
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  4. P.-Y. Lee
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  1. Joseph-Stelzmann-Straße 9, D-5000, Köln 41, Germany

    G. K. Krieglstein (Direktor der Universitäts-Augenklinik Köln) (Direktor der Universitäts-Augenklinik Köln)

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© 1987 Springer-Verlag Berlin Heidelberg

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Podos, S.M., Camras, C.B., Serle, J.B., Lee, PY. (1987). Pharmacologic Alteration of Aqueous Humor Dynamics in Normotensive and Glaucomatous Monkey Eyes. In: Krieglstein, G.K. (eds) Glaucoma Update III. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71785-7_33

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  • DOI: https://doi.org/10.1007/978-3-642-71785-7_33

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-17399-1

  • Online ISBN: 978-3-642-71785-7

  • eBook Packages: Springer Book Archive

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