Abstract
The morphological effect of trabeculoplasty upon the monkey eye was studied by electron microscopy. Irradiations were performed using the argon-ion and the free-running Nd: YAG lasers. Morphological analysis up to thirteen weeks after irradiation shows the following:
-
1.
A thermal coagulation of the inner trabecular sheets occurs during irradiation.
-
2.
A monolayer of corneal-like endothelial cells covers the inner trabecular meshwork in the impact zone four weeks after irradiation.
-
3.
Degeneration of trabecular endothelial cells is observed predominantly in the juxtacanalicular tissue. The process continues throughout the period of observation.
-
4.
Cells with long processes are found to phagocytose and digest fragments of collagen fibrils. These cells are located close to the posterior border of Schlemm’s canal and are most prominent during the later stages of observation.
-
5.
Alongside the degeneration process a limited collagen synthesis is apparent, this being indicated by the presence of a small number of fibroblasts.
These findings suggest that new aspects relating to the mechanism of trabeculoplasty may have to be considered.
This work was supported by the Swiss National Science Foundation, grant number 3.872-0.83, and the Swiss Commission for the Promotion of Scientific Research.
Preview
Unable to display preview. Download preview PDF.
References
Goldberg I (1985) Argon laser trabeculoplasty and the open-angle glaucomas. Aust NZ J Ophthalmol 13:243–248
Holmin C, Bauer B (1984) Laser trabeculoplasty in open angle glaucoma. A short term study using computerized perimetry. Acta Ophthalmol (Copenh) 62:337–341
Koganei J (1885) Untersuchungen über den Bau der Iris des Menschen und der Wirbeltiere. Arch mikrosk Anat 25:1–48
Rodrigues MM, Spaeth GL, Donohoo P (1982) Electron microscopy of argon laser therapy in phakic open-angle glaucoma. Ophthalmology (Rochester) 89:198–210
Rosenthal AR, Chaudhuri PR, Chiapella AP (1984) Laser trabeculoplasty primary therapy in open-angle glaucoma. A preliminary report. Arch Ophthalmol 102:699–701
Schwartz LW, Spaeth GL, Traverso C, Greenidge KC (1983) Variation of techniques on the results of argon laser trabeculoplasty. Ophthalmology (Rochester) 90:781–784
Schwartz AL, Perman KI, Whitten M (1984) Argon laser trabeculoplasty in progressive lowtension glaucoma. Ann Ophthalmol 16:560–562
Schwartz AL, Love DC, Schwartz MA (1985) Long-term follow-up of argon laser trabeculoplasty for uncontrolled open-angle glaucoma. Arch Ophthalmol 103:1482–1484
Tengroth B, Ammitzboll T (1984) Changes in the content and composition of collagen in the glaucomatous eye — Basis for a new hypothesis for the genesis of chronic open angle glaucoma. Acta Ophthalmol (Copenh) 62:999–1008
Weber PA, Davidorf FH, McDonald C (1983) Scanning electron microscopy of argon laser trabeculoplasty. Ophthalmic Forum 1:26–29
Wise JB, Witter SL (1979) Argon laser therapy for open-angle glaucoma. A pilot study. Arch Ophthalmol 97:319–322
Wobmann PR, Fine BS (1972) The clump cells of Koganei. A light and electron microscopic study. Am J Ophthalmol 73:90–101
Van der Zypen E, Fankhauser F (1982) Laser in the treatment of chronic simple glaucoma. Trans Ophthalmol Soc UK 102:147–153
Van der Zypen E, Fankhauser F (1984) Ultrastructural changes of the trabecular meshwork of the monkey (Macaca speciosa) following irradiation with argon laser light. Albrecht Von Graefes Arch Klin Exp Ophthalmol 221:249–261
Van der Zypen E, Fankhauser F, Bebie H, Marshall J (1979) Changes in the ultrastructure of the iris after irradiation with intense light. A study of long-term effects after irradiation with argon ion, Nd: YAG and Q-switched ruby lasers. Adv Ophthalmol 39:59–180
Van der Zypen E, Fankhauser F, England C, Kwasniewska S (1987) Morphology of the trabecular meshwork within monkey (Macaca speciosa) eyes following irradiation with the free-running Nd: YAG laser. Ophthalmology 94: (in press)
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1987 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
van der Zypen, E. (1987). The Effects of Lasers on Outflow Structures. In: Krieglstein, G.K. (eds) Glaucoma Update III. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71785-7_25
Download citation
DOI: https://doi.org/10.1007/978-3-642-71785-7_25
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-17399-1
Online ISBN: 978-3-642-71785-7
eBook Packages: Springer Book Archive