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Adaptation of Dictyostelium Discoideum Cells to Chemotactic Signals

  • Conference paper
Molecular Mechanisms of Desensitization to Signal Molecules

Part of the book series: NATO ASI Series ((ASIH,volume 6))

Abstract

The cellular slime mold Dictyostelium discoideum lives in the soil where it feeds on bacteria. Exhaustion of the food supply induces cell aggregation. Subsequently, cells differentiate to two cell types; spores embedded in a slime droplet on top of a tubular stalk of vacuolized cells. Cell aggregation is mediated by Chemotaxis. Upon starvation some cells start to secrete a chemoattractant which has been identified as cAMP (1). Extracellular cAMP induces two responses, which are both mediated by cell surface receptors. First, cAMP activates adenylate cyclase; the produced cAMP is secreted and may trigger other cells, thus relaying the signal. Second, cAMP induces a chemotactic response by which cells move in the direction of the cAMP source. The combined effects of cAMP relay and Chemotaxis may lead to the accumulation of as many as 100,000 cells in a central collecting point derived from an area of about 1 cm2 (see 2,3 for recent reviews).

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Authors and Affiliations

  1. Cell Biology and Morphogenesis Unit, Zoological Laboratory, University of Leiden, NL-2300 RA, Leiden, the Netherlands

    Peter J. M. Van Haastert, René J. W. De Wit, Pim M. W. Janssens, Fanja Kesbeke, B. Ewa Snaar-Jagalska, Michiel M. Van Lookeren Campagne & Theo M. Konijn

Authors
  1. Peter J. M. Van Haastert
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  2. René J. W. De Wit
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  3. Pim M. W. Janssens
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  4. Fanja Kesbeke
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  5. B. Ewa Snaar-Jagalska
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  6. Michiel M. Van Lookeren Campagne
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  7. Theo M. Konijn
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Editor information

Editors and Affiliations

  1. Zoölogisch Laboratorium, Kaiserstraat 63, Postbus 9516, 2300 RA, Leiden, The Netherlands

    T. M. Konijn  & P. J. M. Van Haastert  & 

  2. Van Beethovenlaan 5, 3161 RV, Rhoon, The Netherlands

    H. Van der Wel

  3. Molecular Pharmacology Group, Department of Biochemistry, University of Glasgow, G12 8QQ, Glasgow, Scotland

    M. D. Houslay

  4. Kennistransfer, University of Leiden, Stationsweg 46, Postbus 9500, 2300 RA, Leiden, The Netherlands

    H. Van der Starre

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© 1987 Springer-Verlag Berlin Heidelberg

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Van Haastert, P.J.M. et al. (1987). Adaptation of Dictyostelium Discoideum Cells to Chemotactic Signals. In: Konijn, T.M., Van der Wel, H., Van Haastert, P.J.M., Houslay, M.D., Van der Starre, H. (eds) Molecular Mechanisms of Desensitization to Signal Molecules. NATO ASI Series, vol 6. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71782-6_3

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  • DOI: https://doi.org/10.1007/978-3-642-71782-6_3

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-71784-0

  • Online ISBN: 978-3-642-71782-6

  • eBook Packages: Springer Book Archive

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