Cell Responses to Phosphoinositide-Hydrolysing Receptors: Some Potential Sites of Modulation

  • Colin W. Taylor
Conference paper
Part of the NATO ASI Series book series (volume 6)


Many receptors, originally grouped together as Ca2+-mobilising receptors, are now known to share an ability to couple to phospholipase C and to thereby stimulate hydrolysis of a specific class of phospholipids, the phosphoinositides. An important consequence of activation of phospholipase C is that two intracellular products are generated. One of these, inositol 1,4,5-trisphosphate ((1,4,5)IP3, is water-soluble and enters the cytosol; the second product, 1,2 diacylglycerol (DG), remains in the plasma membrane. In addition to their roles as intracellular signal molecules, both (1,4,5)IP3 and DG are substrates for further metabolic pathways that may either inactivate their signalling properties or perhaps generate further intracellular messengers. Clearly, by comparison with receptors that regulate adenylate cyclase activity or the permeability of ion channels, the phosphoinositide-hydrolysing receptors control a more complex signalling pathway.


Adenylate Cyclase Phosphatidic Acid Endoplasmic Reticulum Calcium Intracellular Signal Molecule Complex Signalling Pathway 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Akhtar, R.A. & Abdel-Latif, A.A. (1986). J. Neurochem. 46, 96–104.PubMedCrossRefGoogle Scholar
  2. Allison, J.H., Blisner, M.E., Holland, W. H., Hipps, P.P. & Sherman, W.R. (1976). Biochem. Biophys. Res. Commun. 71, 664–670.PubMedCrossRefGoogle Scholar
  3. Barrowman, M.M., Cockcroft, S. & Gomperts, B.D. (1986). Nature (London) 319, 504–507.CrossRefGoogle Scholar
  4. Batty, I.R., Nahorski, S. R. & Irvine, R.F. (1985). Biochem. J. 232, 211–215.PubMedGoogle Scholar
  5. Berridge, M.J. (1984). Adv. Cyclic Nucleotide Res. 17, 329–335.Google Scholar
  6. Berridge, M.J. & Irvine, R.F. (1984) Nature (London) 320, 631–633.Google Scholar
  7. Burgess, G. M., McKinney, J.S., Irvine, R.F. & Putney, J.W. Jr. (1985). Biochem. J. 232, 237–243.PubMedGoogle Scholar
  8. Clapper, D.L. & Lee, H.C. (1985). J. Biol. Chem. 260, 13947–13954.PubMedGoogle Scholar
  9. Colucci, W.S. & Alexander, R.W. (1986). Proc. Natl. Acad. Sci. USA 83, 1743–1746.PubMedCrossRefGoogle Scholar
  10. Dawson, A.P. (1984). FEBS Lett. 185, 147–150.CrossRefGoogle Scholar
  11. Downes, C.P. & Stone, M.A. (1986). Biochem. J. 234, 199–204.PubMedGoogle Scholar
  12. Drummond, A. H. & Raeburn, C.A. (1984). Biochem. J. 224, 129–136.PubMedGoogle Scholar
  13. Evans, T., Hepler, J.R., Masters, S.B., Brown, J.H., & Harden, T.K. (1985). Biochem. J. 232, 751–757.PubMedGoogle Scholar
  14. Fleischman, L.F., Chahwala, S.B. & Cantley, L. (1986). Science 231, 407–410.PubMedCrossRefGoogle Scholar
  15. Gibbs, J.B., Sigal, I.S., Poe, M. & Scolnick, E.M. (1984). Proc. Natl. Acad. Sci. USA 81, 5704–5708.PubMedCrossRefGoogle Scholar
  16. Irvine, R.F., Letcher, A. J., Heslop, J.P. & Berridge, M.J. (1986). Nature (London). 320, 631–634.CrossRefGoogle Scholar
  17. Itoh, H., Okajima, F. & Ui, M. (1984). J. Biol. Chem. 259, 15464–15473.PubMedGoogle Scholar
  18. Janowsky, A., Labarca, R. & Paul, S.M. (1984). Eur. J. Pharmacol. 102, 193–194.PubMedCrossRefGoogle Scholar
  19. Katada, T., Gilman, A. G., Watanabe, Y., Bauer, S. & Jakobs, K.H. (1985). Eur. J. Biochem. 151, 41–437.CrossRefGoogle Scholar
  20. Kent, R.S. & DeLean, A. & Lefkowitz, R. J. (1980). Mol. Pharmacol. 17, 14–23.PubMedGoogle Scholar
  21. Leeb-Lundberg, L.M.F., Cotecchia, S., Lomasney, J.W., DeBarnardis, J.F., Lefkowitz, R. J. & Caron, M. G. (1985). Proc. Natl. Acad. Sci. USA 82, 5651–5655.PubMedCrossRefGoogle Scholar
  22. Litosch, I., Wallis, C. & Fain, J.N. (1985). J. Biol. Chem. 260, 5464–5471.PubMedGoogle Scholar
  23. Lynch, C.J., Charest, R., Bocckino, S.B., Exton, J.H. & Blackmore, P.F. (1985). J. Biol. Chem. 260, 2844–2851.PubMedGoogle Scholar
  24. Martin, T.F.J., Lucas, D.O., Bajjalieh, S.M. & Kowalchyk, J.A. (1986). J. Biol. Chem. 261, 2918–2927.PubMedGoogle Scholar
  25. Pollock, W.K. & Maclntyre, D.E. (1986). Biochem. J 234, 67–73.PubMedGoogle Scholar
  26. Putney, J.W. Jr. (1986). Cell Calcium 7, 1–12.PubMedCrossRefGoogle Scholar
  27. Rodbell, M. (1985). Trends Biochem. Sci. 10, 461–464.CrossRefGoogle Scholar
  28. Spat, A., Bradford, P.G., McKinney, J.S., Rubin, R.P. & Putney, J.W. Jr. (1986). Nature (London) 319, 514–516.CrossRefGoogle Scholar
  29. Stephenson, R.P. (1956). Br. J. Pharmacol. 11, 379–393.Google Scholar
  30. Storey, D.J., Shears, S. B., Kirk, C.J. & Michell, R.H. (1984). Nature (London) 312, 374–376.CrossRefGoogle Scholar
  31. Streb, H., Irvine, R.F., Berridge, M.J. & Schulz, I. (1983). Nature (London) 306, 67–69.CrossRefGoogle Scholar
  32. Sweet, R.W., Yokoyama, S., Kamata, T., Feramisco, J.R., Rosenberg, M. & Gross, M. (1984). Nature (London) 321, 273–275.CrossRefGoogle Scholar
  33. Taylor, C.W. & Merritt, J.E. (1986). Trends Pharmacol. Sci. (in press).Google Scholar
  34. Taylor, C.W., Merritt, J.E., Putney, J.W. Jr. & Rubin, R.P. (1986). Biocem. J. (in press).Google Scholar
  35. Taylor, M.V., Metcalfe, J.C., Hesketh, T. R., Smith, G.A. & Moore, J.A. (1984). Nature (London) 312, 462–465.CrossRefGoogle Scholar
  36. Ueda, T., Cheuh, S-H., Noel, M. W. & Gill, D.L. (1986). J. Biol. Chem. 261, 3184–3192.PubMedGoogle Scholar
  37. Uhing, R.J., Prpic, V., Jiang, H. & Exton, J.H. (1986). J. Biol. Chem. 261, 2140–2146.PubMedGoogle Scholar
  38. Van Dongen, C.J., Zwiers, H., DeGraan, P.N.E. & Gispen, W. H. (1985). Biochem. Biophys. Res. Commun. 128, 1219–1227.PubMedCrossRefGoogle Scholar
  39. Weiss, S.J. & Putney, J.W. Jr. (1980). Biochem. J. 194, 46 3–468.Google Scholar
  40. Wolf, M., LeVine, H., May, S.W. Jr., Cuatrecasas, P. & Sahyoun, N. (1985). Nature (London) 317, 546–549.CrossRefGoogle Scholar
  41. Zatz, M. (1985). J. Neurochem. 45, 95–100.PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • Colin W. Taylor
    • 1
  1. 1.Department of ZoologyCambridgeUK

Personalised recommendations