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Cell Responses to Phosphoinositide-Hydrolysing Receptors: Some Potential Sites of Modulation

  • Colin W. Taylor
Conference paper
Part of the NATO ASI Series book series (volume 6)

Abstract

Many receptors, originally grouped together as Ca2+-mobilising receptors, are now known to share an ability to couple to phospholipase C and to thereby stimulate hydrolysis of a specific class of phospholipids, the phosphoinositides. An important consequence of activation of phospholipase C is that two intracellular products are generated. One of these, inositol 1,4,5-trisphosphate ((1,4,5)IP3, is water-soluble and enters the cytosol; the second product, 1,2 diacylglycerol (DG), remains in the plasma membrane. In addition to their roles as intracellular signal molecules, both (1,4,5)IP3 and DG are substrates for further metabolic pathways that may either inactivate their signalling properties or perhaps generate further intracellular messengers. Clearly, by comparison with receptors that regulate adenylate cyclase activity or the permeability of ion channels, the phosphoinositide-hydrolysing receptors control a more complex signalling pathway.

Keywords

Adenylate Cyclase Phosphatidic Acid Endoplasmic Reticulum Calcium Intracellular Signal Molecule Complex Signalling Pathway 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • Colin W. Taylor
    • 1
  1. 1.Department of ZoologyCambridgeUK

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