Regression of Atherosclerosis in Man

  • A. G. Olsson


Methods to determine whether regression of atherosclerosis is possible in man must be indirect. Two principal methods used to demonstrate regression can be discussed: patho-anatomical studies on autopsy material, and visualisation of atheroma in vivo by other means.


Irregularity Index Atheroma Change Edge Irregularity Cholestyramine Therapy Femoral Atherosclerosis 
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  1. 1.
    Aschoff L (1924) Atherosclerosis. In: Lectures in pathology (delivered in the United States, 1924 ). Hoeber, New YorkGoogle Scholar
  2. 2.
    Malinow MR (1984) Regression of atherosclerosis in humans: anatomical evidence from post mortem studies. In Malinow MR, Blaton VH (eds) Regression of atherosclerotic lesions: experimental studies and observations in humans. Plenum, New York, pp 329–337 (Life Sciences, vol 79 )Google Scholar
  3. 3.
    Wanscher O, Clemmesen J, Neilson A (1951) Negative correlation between atherosclerosis and carcinoma. Br J Cancer 5: 172PubMedCrossRefGoogle Scholar
  4. 4.
    Blankenhorn DH, Brooks SH, Selzer RH, Barndt R (1978) The rate of atherosclerosis change during treatment of hyperlipoproteinemia. Circulation 57: 355PubMedGoogle Scholar
  5. 5.
    Olsson AG, Erikson U, Helmius G, Hemmingsson A, Ruhn G (1984) Regression of femoral atherosclerosis in humans: methodological and clinical problems associated with studies on femoral atherosclerosis development as assessed by angiograms. In Malinow MR, Blaton VH (eds) Regression of atherosclerotic lesions: experimental studies and observations in humans. Plenum, New York, p 311 (Life Sciences, vol 79 )Google Scholar
  6. 6.
    De Rouen TA, Murray JA, Owen W (1977) Variability in the analysis of coronary arteriograms. Circulation 55: 324Google Scholar
  7. 7.
    Brensike JF, Levy RI, Kelsey SF et al (1984) Effects of therapy with cholestyramine on progression of coronary arteriosclerosis: results of the NHLBI type II coronary intervention study. Circulation 69: 313PubMedCrossRefGoogle Scholar
  8. 8.
    Blankenhorn DH, Brooks SH (1981) Angiographic trial of lipid-lowering therapy. Arteriosclerosis 1: 242Google Scholar
  9. 9.
    Brown BG, Bolson EL, Dodge HT (1982) Artériographie assessment of coronary atherosclerosis: review of current methods, their limitations, and clinical applications. Arteriosclerosis 2: 2PubMedCrossRefGoogle Scholar
  10. 10.
    Hamsten A, Walldius G, Szamosi A et al (1986) Relationship of angiographically defined coronary artery disease to serum lipoproteins and apolipoproteins in young survivors of myocardial infarction. In: Hamsten A, Studies on Myocardial Infarction at Young Age, thesis, Karolinska InstituteGoogle Scholar
  11. 11.
    Nikkilâ EA, Viikinkoski P, Valle M, Frick MH (1984) Prevention of progression of coronary artherosclerosis by treatment of hyperlipidaemia: a seven year prospective angiographic study. Br Med J 289: 220CrossRefGoogle Scholar
  12. 12.
    Levy RI, Brensike JF, Epstein SE et al (1984) The influence of changes in lipid values induced by cholestyramine and diet on progression of coronary artery disease: results of the NHLBI type II coronary intervention study. Circulation 69: 325PubMedCrossRefGoogle Scholar
  13. 13.
    Detre KM, Kelsey SF, Levy RI (1985) Effects of cholestyramine on incidence of morbidity and mortality: NHLBI type II coronary intervention study. Council on Arteriosclerosis, American Society for the study of arteriosclerosis, Washington, DC, November 1985. Arteriosclerosis 5: 512aGoogle Scholar
  14. 14.
    Kramer JR, MatsudaY, Mulligan DO (1981) Progression of coronary atherosclerosis. Circulation 63: 519Google Scholar
  15. 15.
    Arntzenius AC, Kromhout D, Barth J et al (1985) Diet, lipoproteins, and the progression of coronary atherosclerosis. N Engl J Med 312: 805PubMedCrossRefGoogle Scholar
  16. 16.
    Blankenhorn DH (1984) Progress report on a lipid-lowering trial in men with coronary bypass surgery. In: Carlson LA, Olsson AG (eds) Treatment of hyperlipoproteinemia. Raven, New York, p 211Google Scholar
  17. 17.
    Duffield RGM, Miller NE, Brunt JNH et al (1983) Treatment of hyperlipidaemia retards progression of symptomatic femoral atherosclerosis: a randomised controlled trial. Lancet II: 639CrossRefGoogle Scholar
  18. 18.
    Olsson AG, Erikson U, Helmius G et al (1986) The effect of pronounced serum lipid lowering for one year on the development of femoral atherosclerosis in asymptomatic hyperlipoproteinemia. In: Fidge NH, Nestel PJ (eds) Olsson AG, Erikson U, Helmius G et al VII. Excerpta MedicaGoogle Scholar
  19. 19.
    Crawford DW, Brooks SH, Selzer RH et al (1977) Computer densitometry for angiographic assessment of arterial cholesterol content and gross pathology in human atherosclerosis. J Lab Clin Med 89: 378PubMedGoogle Scholar

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© Springer-Verlag Berlin Heidelberg 1987

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  • A. G. Olsson

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