Arenaviruses pp 131-143 | Cite as

Nature of the Inflammatory Process in the Central Nervous System of Mice Infected with Lymphocytic Choriomeningitis Virus

  • J. E. Allan
  • J. E. Dixon
  • P. C. Doherty
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 134)


Lymphocytic choriomeningitis (LCM) is an inflammatory disease that occurs in immunologically competent adult mice after infection of the brain with LCM virus (LCMV). Tremors develop in the legs, head, and tail, and characteristic extensor spasms of the hind legs are found during the terminal stage of disease, usually within 1 week of infection.


Adoptive Transfer Recipient Mouse Viral Meningitis Lymphocytic Choriomeningitis Hybrid Resistance 
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  1. Allan JE, Doherty PC (1985 a) Immune T cells can protect or induce fatal neurological disease in murine lymphocytic choriomeningitis. Cell Immunol 90: 401–407PubMedCrossRefGoogle Scholar
  2. Allan JE, Doherty PC (1985 b) Consequences of a single Ir-gene defect for the pathogenesis of lymphocytic choriomeningitis. Immunogenetics 21: 581–589PubMedCrossRefGoogle Scholar
  3. Allan JE, Doherty PC (1985 c) Consequences of cyclophosphamide treatment in murine lymphocytic choriomeningitis: evidence for cytotoxic T cell replication in vivo. Scand J Immunol 22: 367–379PubMedCrossRefGoogle Scholar
  4. Allan JE, Doherty PC (1986) Natural killer cells contribute to inflammation but do not appear to be essential for the induction of clinical lymphocytic choriomeningitis. Scand J Immunol 24: 153–162PubMedCrossRefGoogle Scholar
  5. Austyn JM, Gordon S (1981) F4/80: a monoclonal antibody directed specifically against the mouse macrophage. Eur J Immunol 10: 805–811CrossRefGoogle Scholar
  6. Baenziger J, Herngartner H, Zinkernagel RM, Cole GA (1986) Induction or prevention of immuno-pathological disease by cloned cytotoxic T cell lines specific for lymphocytic choriomeningitis virus. Eur J Immunol 16: 387–393PubMedCrossRefGoogle Scholar
  7. Byrne JA, Oldstone MBA (1984) Biology of cloned cytotoxic T lymphocytes specific for lymphocytic choriomeningitis virus: clearance of virus in vivo. J Virol 51: 682–686PubMedGoogle Scholar
  8. Buchmeier MJ, Welsh RM, Dutko FJ, Oldstone MBA (1980) The virology and immunobiology of lymphocytic choriomeningitis virus infection. Adv Immunol 30: 275–331PubMedCrossRefGoogle Scholar
  9. Camenga DL, Walker DH, Murphy FA (1977) Anticonvulsant prolongation of survival in adult murine lymphocytic choriomeningitis. I. Drug treatment and virologic studies. J Neuropathol Exp Neurol 36:9–20PubMedCrossRefGoogle Scholar
  10. Clark EA, Harmon RC (1980) Genetic control of natural cytotoxicity and hybrid resistance. Adv Cancer Res 31: 227–285PubMedCrossRefGoogle Scholar
  11. Doherty PC (1973) Quantitative studies of the inflammatory process in fatal viral meningoencephalitis. Am J Pathol 73: 607–622PubMedGoogle Scholar
  12. Doherty PC, Allan JE (1985) Participation of cyclophosphamide-resistant T cells in murine lymphocytic choriomeningitis. Scand J Immunol 21: 127–132PubMedCrossRefGoogle Scholar
  13. Doherty PC, Allan JE (1986) Hybrid resistance modulates the inflammatory process induced by lymphocytic choriomeningitis virus-immune T cells. Immunology 57: 515–519PubMedGoogle Scholar
  14. Doherty PC, Korngold R (1983) Hierarchies of T cell responsiveness are reflected in the distribution of effector T cells in viral meningitis. Aust J Exp Med SCi 61: 471-475 CrossRefGoogle Scholar
  15. Doherty PC, Zinkernagel RM (1974) T-cell-mediated immunopathology in viral infections. Transplant Rev 19: 89–120PubMedGoogle Scholar
  16. Doherty PC, Dunlop MBC, Parish CR, Zinkernagel RM (1976) Inflammatory process in murine lymphocytic choriomeningitis is maximal in H-2K or H-2D compatible interactions. J Immunol 117:187–190PubMedGoogle Scholar
  17. Hurwitz JL, Korngold R, Doherty PC (1983) Specific and nonspecific T-cell recruitment in viral meningitis: possible implications for autoimmunity. Cell Immunol 76: 397–401PubMedCrossRefGoogle Scholar
  18. Johnson ED, Monjan AA, Morse HC III (1978) Lack of B-cell participation in acute lymphocyte choriomeningitis disease of the central nervous system. Cell Immunol 36: 143–150PubMedCrossRefGoogle Scholar
  19. Lehmann-Grube F (1982) The mouse in biomedical research, vol 2 Diseases. Academic, New YorkGoogle Scholar
  20. Longo DL, Schwartz RH (1980) T-cell specificity for H-2 and Ir gene phenotype correlates with the phenotype of thymic antigen-presenting cells. Nature 287:44–46PubMedCrossRefGoogle Scholar
  21. Nathanson N, Monjan AA, Panitch HJ, Johnson ED, Petursson G, Cole GA (1975) Viral immunology and immunopathology. Academic, New YorkGoogle Scholar
  22. Orn A, Goodenow RS, Hood L, Brayton PR, Woodward JG, Harmon RC, Frelinger JA (1982) Product of a transferred H-2Ld gene acts as a restriction element for LCMV-specific killer T cells. Nature 297:415–417PubMedCrossRefGoogle Scholar
  23. Perry VH, Hume DA, Gordon S (1985) Immunohistochemical localization of macrophages and microglia in the adult and developing mouse brain. Neuroscience 15: 313–326PubMedCrossRefGoogle Scholar
  24. Schwendemann G, Lohler J, Lehmann-Grube F (1983) Evidence for cytotoxic T-lymphocyte-target cell interaction in brains of mice infected intracerebrally with lymphocytic choriomeningitis virus. Acta Neuropathol (Berl) 61: 183–195CrossRefGoogle Scholar
  25. Sprent J, Korngold R (1983) A comparison of lethal graft-vs-host disease to minor-vs-major histocompatibility differences in mice: implications for marrow transplantation in man. Progress in Immunology V: 1461–1475Google Scholar
  26. Thomsen AR, Volkert M, Marker O (1979) The timing of the immune response in relation to virus growth determines the outcome of the LCM infection. Acta Pathol Microbiol Scand [C] 87:47–54Google Scholar
  27. Walker DH, Murphy FA, Whitfield SG, Baver SP (1975) Lymphocytic choriomeningitis: ultrastructural pathology. Exp Mol Pathol 23: 245–265PubMedCrossRefGoogle Scholar
  28. Zinkernagel RM, Doherty PC (1973) Cytotoxic thymus derived lymphocytes in cerebrospinal fluid of mice with lymphocytic choriomeningitis. J Exp Med 138: 1266–1269PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin · Heidelberg 1987

Authors and Affiliations

  • J. E. Allan
    • 1
  • J. E. Dixon
    • 1
  • P. C. Doherty
    • 1
  1. 1.Department of Experimental Pathology, John Curtin School of Medical ResearchAustralian National UniversityCanberra CityAustralia

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