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Arenaviruses pp 117–130Cite as

Neutralization of Arenaviruses by Antibody

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Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 134))

Abstract

Neutralization of infectivity is the end result of a number of alternative or synergistic reactions between a virus and antibody directed against certain antigenic determinants on its surface. These reactions prevent either the attachment of virus to a particular host cell by steric hindrance, the entry of virus into the cell, or the uncoating of the virus particle to release the viral genome. In turn, the relative contribution of each of these to neutralization is dependent both on qualities of the viral antibodies (their relative affinities and immunoglobulin class) and specificity for relevant antigenic determinants (so-called critical sites). These considerations have been the subjects of several extensive reviews (Mandel 1979; Della-Porta and Westaway 1978).

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References

  • Allison LM, Salter M, Buchmeier MJ, Lewicki H, Howard CR (1984) Neutralization of arenaviruses: reaction of Tacaribe virus and variants with monoclonal antibodies. In: Compans RW, Bishop DHJL (eds) Segmented negative strand viruses. Academic, New York, pp 209–216

    Google Scholar 

  • Barrera Oro JG, Grela ME, Zannoli VH, Garcia CA (1977) Anticuerpos contra viruses Junin y LCM en casos presuntiros de fiebre hemorragica Argentina. Medicina (B Aires) 37: 69–77

    Google Scholar 

  • Bruns M, Cinak J, Muller G, Lehmann-Grube G (1983) Lymphocytic choriomeningitis virus. VI: Isolation of a glycoprotein mediating neutralization. Virology 130: 247–251

    Article  PubMed  CAS  Google Scholar 

  • Buchmeier MJ (1984) Antigenic and structural studies on the glycoproteins of lymphocytic choriomeningitis virus. In: Compans RW, Bishop DHL (eds) Segmented negative strand viruses. Academic, New York, pp 193–200

    Google Scholar 

  • Buchmeier MJ, Gee SR, Rawls WE (1977) Antigens of Pichinde virus. I: Relationship of soluble antigens derived from infected BHK-21 cells to the structural components of the virion. J Virol 22: 175–186

    PubMed  CAS  Google Scholar 

  • Buckley SM, Casals J (1970) Lassa fever, a new virus disease of man from West Africa. III: Isolation and characterization of the virus. Am J Trop Med Hyg 19: 680–691

    PubMed  CAS  Google Scholar 

  • Carballal G, Frigerio MJ (1973) Accion de los inmunosueros sobre la respuesta inmune et la fiebre hemorragica experimental. Medicina (B Aires) 23: 68–77

    Google Scholar 

  • Chanas AC, Mann G, Young P, Ellis DS, Stamford S, Howard CR (1980) Evaluation of plaque size reduction as a method for the detection of Pichinde virus antibody. Arch Virol 65: 157– 167

    Article  PubMed  CAS  Google Scholar 

  • Coto CE, Weissenbacher MC, Calello MA (1976) Proteccion del cabayo contra la fiebre hemorragica Argentina por innoculation de virus del complejo Tacaribe. Medicina (B Aires) 36: 9–16

    CAS  Google Scholar 

  • Coto CE, Damonte EB, Calello MA, Weissenbacher MC (1980) Protection of guinea pigs inoculated with Tacaribe virus against lethal doses of Junin virus. J Infect Dis 141: 389–393

    Article  PubMed  CAS  Google Scholar 

  • Coulombie FC, Damonte EB, Coto CE (1984) Influencia de la celula huesped en las reacciones de neutralizacion cruzada entre virus Junin y Tacaribe. Rev Argent Microbiol 16: 159–164

    PubMed  CAS  Google Scholar 

  • Damonte EB, Coto CE, Calello MA, Weissenbacher MC (1978) Inmunization heterologa contra virus Junin. Medicina (B Aires) 38: 226–232

    CAS  Google Scholar 

  • Della-Porta AJ, Westaway EG (1978) A multi-hit model for the neutralization of animal viruses. J Gen Virol 38: 1–19

    Article  PubMed  CAS  Google Scholar 

  • Eddy GA, Cole FE Jr (1978) The development of a vaccine against African hemorrhagic fever. In: Patyn SR (ed) Ebola virus haemorrhagic fever. Elsevier, Amsterdam, pp 237–242

    Google Scholar 

  • Eddy GA, Wagner FS, Scott SK, Mahlandt BJ (1975) Protection of monkeys against Machupo virus by the passive administration of Bolivian haemorrhagic fever immunoglobulin (human origin). Bull WHO 52:723–727

    PubMed  CAS  Google Scholar 

  • Enria DA, Briggiler AM, Fernandez NJ, Levis SC, Maiztegui JI (1984) Importance of dose of neutralizing antibodies in treatment of Argentine haemorrhagic fever with immune plasma. Lancet II:255–256

    Article  Google Scholar 

  • Fazekas de St Groth S (1962) The neutralization of viruses. Adv Virus Res 9: 1–125

    Google Scholar 

  • Frame JD, Baldwin JM Jr, Gocke DJ, Troup JM (1970) Lassa fever, a new virus disease of man from West Africa. I: Clinical description and pathological findings. Am J Trop Med Hyg 19: 670–676

    PubMed  CAS  Google Scholar 

  • Henderson JR, Downs WG (1965) Junin and Tacaribe plaque reduction in rhesus monkey kidney cell monolayers. Am J Trop Med Hyg 14: 796–797

    PubMed  CAS  Google Scholar 

  • Hotchin J (1962) The biology of lymphocytic choriomeningitis infection: virus induced immune disease. Cold Spring Harbour Symp Quant Biol 27:479–499

    CAS  Google Scholar 

  • Hotchin J, Kinch W (1975) Microplaque reduction: new assay for neutralizing antibody to lymphocytic choriomeningitis virus. J Infect Dis 131: 186–188

    Article  PubMed  CAS  Google Scholar 

  • Howard CR, Lewicki H, Allison L, Salter M, Buchmeier MJ (1985) Properties and characterization of monoclonal antibodies to Tacaribe virus. J Gen Virol 66: 1383–1395

    Article  PubMed  Google Scholar 

  • Iorio RM, Bratt M (1984) Neutralization of Newcastle disease virus by monoclonal antibodies to haemagglutinin neuraminidase glycoprotein: requirement for antibodies to four sites for complete neutralization. J Virol 51: 445–451

    PubMed  CAS  Google Scholar 

  • Jahrling PB (1983) Protection of Lassa virus-infected guinea pigs with Lassa-immune plasma of guinea pig, primate and human origin. J Med Virol 12: 93–102

    Article  PubMed  CAS  Google Scholar 

  • Jahrling PB, Peters CJ (1984) Passive antibody therapy of Lassa fever in cynomolgus monkeys: importance of neutralizing antibody and Lassa virus strain. Infect Immun 44: 528–533

    PubMed  CAS  Google Scholar 

  • Jahrling PB, Hesse RA, Eddy GA, Johnson KM, Callis RT, Stephen EL (1980) Lassa virus infection of rhesus monkeys: pathogenesis and treatment with ribavirin. J Infect Dis 141: 580–589

    Article  PubMed  CAS  Google Scholar 

  • Jahrling PB, Smith S, Hesse RA, Rhoderick JB (1982) Pathogenesis of Lassa virus infection in guinea pigs. Infect Immun 37: 771–778

    PubMed  CAS  Google Scholar 

  • Johnson KM, Webb PA, Justines G (1973) Biology of Tacaribe-complex viruses. In: Lehmann-Grube F (ed) Lymphocytic choriomeningitis virus and other arenaviruses. Springer, Berlin Heidelberg New York, pp 241–258

    Google Scholar 

  • Lehmann-Grube F (1971) Lymphocytic choriomeningitis virus. Virology monographs, vol 10. Springer, Berlin Heidelberg New York

    Google Scholar 

  • Lehmann-Grube F, Kallay M, Ibscher B, Schwartz R (1979) Serologic diagnosis of human infections with lymphocytic choriomeningitis virus: comparative evaluation of seven methods. J Med Virol 4: 125–136

    Article  PubMed  CAS  Google Scholar 

  • Leifer E, Gocke DJ, Bourne H (1970) Lassa fever, a new virus disease of man from West Africa. II: Report of a laboratory-acquired infection treated with plasma from a person recently recovered from the disease. Am J Trop Med Hyg 19: 677–679

    PubMed  CAS  Google Scholar 

  • Levis SC, Saavedra MC, Ceccoli C, Falcoff E, Feuillade MR, Enria DAM, Maiztegui JI, Falcoff R (1984) Endogenous interferon in Argentine haemorrhagic fever. J Infect Dis 149: 428–433

    Article  PubMed  CAS  Google Scholar 

  • Maiztegui JI, Sabattini MS, Barrera Oro JG (1972) Actividad del virus de la coriomeningitis linfocitica (LCM) en el area endemica de fiebre hemorragica Argentina (FHA). I: Estudios serologicos en rodeores capturados en la ciudad de pergamino. Medicina (B Aires) 32: 131–137

    CAS  Google Scholar 

  • Maiztegui JI, Fernandez NJ, de Damilano AJ (1979) Efficacy of immune plasma in treatment of Argentine haemorrhagic fever and association between treatment and a late neurological syndrome. Lancet II: 1216–1217

    Article  Google Scholar 

  • Mandel B (1979) Interactions of viruses with neutralizing antibodies. In: Fraenkel-Conrat H, Wagner RR (eds) Comprehensive virology, vol 15. Plenum, New York, pp 37–121

    Chapter  Google Scholar 

  • Monath TP, Maher M, Casals J, Kissling RE, Cacciapuoti A (1974) Lassa fever in the eastern province of Sierra Leone, 1970–1972. II: Clinical observations and virological studies on selected hospital cases. Am J Trop Med Hyg 23: 1140–1149

    PubMed  CAS  Google Scholar 

  • Sabattini MS, Barrera Oro JG, Maiztegui JI, Ferradas BR de (1974) Actividad del virus de la coriomeningitis linfocitica en el area endemica de fiebre hemorragica Argentina. II: Aislamiento a partir de un Mus musculus campestre capuado en el sudeste de Cordoba. Medicina (B Aires) 34:313

    CAS  Google Scholar 

  • Sengupta S, Rawls WE (1979) Pseudotypes of vesicular stromatitis virus and Pichinde virus. J Gen Virol 42: 141–148

    Article  PubMed  CAS  Google Scholar 

  • Szmuness W (1978) Hepatocellular carcinoma and the hepatitis B virus: evidence for a causal association. Prog Med Virol 24: 40–69

    PubMed  CAS  Google Scholar 

  • Tauraso NM, Shelokov A (1965) Protection against Junin virus by immunization with live Tacaribe virus. Proc Soc Exp Biol Med 119: 608–611

    PubMed  CAS  Google Scholar 

  • Teyssie AR, Gutman Frugone LF, Ayerra de Holstein B, Barrera Oro JG (1971) Nivel de anticuerpos contra virus Junin en un grupo de personal de laboratorio. Medicina (B Aires) 31: 113–116

    Google Scholar 

  • Volk WA, Snyder RM, Benjamin DC, Wagner RR (1982) Monoclonal antibodies to the glycoprotein of vesicular stomatitis virus: comparative neutralizing activity. J Virol 42: 220–227

    PubMed  CAS  Google Scholar 

  • Webb PA, Johnson KM, MacKenzie RB (1969) The measurement of specific antibodies in Bolivian haemorrhagic fever by neutralization of virus plaques. Proc Soc Exp Biol Med 130: 1013–1019

    PubMed  CAS  Google Scholar 

  • Weissenbacher MC, Coto CE, Calello MA (1975/1976) Cross-protection between Tacaribe complex viruses. Protection of neutralizing antibodies against Junín virus (Argentine hemorrhagic fever) in guinea pigs infected with Tacaribe virus. Intervirology 6: 42–49

    Article  PubMed  Google Scholar 

  • Weissenbacher MC, Edelmuth E, Firgerio MJ, Coto CE, de Guerrero LB (1980) Serological survey to detect subclinical Junín virus infection in laboratory personnel. J Med Virol 6: 223–226

    Article  PubMed  CAS  Google Scholar 

  • Weissenbacher MC, Coto CE, Calello MA, Rondinone SN, Damonte EB, Frigerio MJ (1982) Cross-protection in non-human primates against Argentine hemorrhagic fever. Infect Immun 35:425–430

    PubMed  CAS  Google Scholar 

  • Wulff H, Lange JV (1975) Indirect immunofluorescence for the diagnosis of Lassa fever infections. Bull WHO 52:429–436

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Medical Microbiology, London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK

    C. R. Howard

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  1. C. R. Howard
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Editors and Affiliations

  1. Department of Immunology, Scripps Clinic and Research Foundation, 10666 North Torrey Pines Road, La Jolla, CA, 92037, USA

    Michael B. A. Oldstone M.D.

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© 1987 Springer-Verlag Berlin · Heidelberg

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Howard, C.R. (1987). Neutralization of Arenaviruses by Antibody. In: Oldstone, M.B.A. (eds) Arenaviruses. Current Topics in Microbiology and Immunology, vol 134. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71726-0_5

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  • DOI: https://doi.org/10.1007/978-3-642-71726-0_5

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-71728-4

  • Online ISBN: 978-3-642-71726-0

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