New Trends in the Treatment of Onychomycosis

  • S. Nolting
  • S. Stettendorf
  • W. Ritter
Conference paper

Abstract

Two years have passed since we reported, for the first time, a new approach to the treatment of onychomycosis. Since that time we have recorded increasingly practice-oriented results and gained useful experience. The administration of bifonazole 1% in 40% urea ointment made it possible to carry the active substance (bifonazole) direct to the fungus, thus successfully solving the problem of nails infected by the fungi. Up to now it has been impossible to tackle the problem of fungi which are protected by keratin.

Preliminary results suggest that the new therapeutic agent containing 1% bifonazole and 40% urea ointment facilitates avulsion of the infected nail, avoiding operative removal of the nail as a rule. In this connection, therapeutic success is not only dependent on the application and efficacy of a preparation, but on the compliance of the patient and his/her efforts to contribute to the success of treatment.

Keywords

Hydration Urea Hexane Chloroform Toluene 

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References

  1. Nolting S, Fegeier K (1982) Medizinische Mykologie. Springer, Berlin Heidelberg New YorkGoogle Scholar
  2. Nolting S (1984) Dermatologica 169, Suppl 1: 117Google Scholar
  3. Ritter W (1982) The Autospotter in drug level determination from body fluids. In: Kaiser RE (ed), Instrumental high-performance thin-layer chromatography. Bad Dürkheim, pp 114–119Google Scholar
  4. Ritter W, Stettendorf S, Weber H (1982) Pharmacokinetics of bifonazole and their clinical implications. In: Urabe U, Zaias N, Stettendorf S (eds) International antifungal symposium: Bifonazole, Tokyo. Excerpta Medica, Amsterdam, pp 48–53Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • S. Nolting
    • 1
  • S. Stettendorf
  • W. Ritter
  1. 1.Department of DermatologyUniversity of MünsteMünsterFederal Republic of Germany

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