Abstract
The thermodynamic cycle--perturbation method is a new theoretical approach for predicting how alterations in molecular structure will change the thermodynamics of any of a large number of possible molecular processes (1–7). The structural alteration might for example be a single-site mutation in a protein or a chemical modification of a drug molecule. The process of interest might be the folding of a protein, the binding of a ligand to a receptor, the association of a repressor protein to an operator region of DNA, etc.; and the thermodynamic quantity to be predicted might be a relative free energy of folding or binding, an entropy or enthalpy of activation, or any other quantity.
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References
Tembe, B. L. and McCammon, J. A. (1984) Comput. Chem. 8, 281–283.
Lybrand, T. P., McCammon, J. A. and Wipff, G. (1986) Proc. Natl. Acad. Sci. USA 83, 833–835.
McCammon, J. A., Karim, O. A., Lybrand, T. P. and Wong, C. F. (1986) Ann. N. Y. Acad. Sci., in press.
Wong, C. F. and McCammon, J. A. (1986) J. Amer. Chem. Soc., in press.
Wong, C. F. and McCammon, J. A. (1986) Isr. J. Chem., in press.
McCammon, J. A. and Harvey, S. C. (1986) Dynamics of Proteins and Nucleic Acids, Cambridge Univ. Press, London, in press.
Brooks, C. L. (1986) J. Phys. Chem., in press.
Berkowitz, M. and McCammon, J. A. (1982) Chem. Phys. Lett. 90, 215–217.
Brooks, C. L., Brunger, A. and Karplus, M. (1985) Biopolymers 23, 843–865.
Karplus, M. and McCammon, J. A. (1986) Sci. Amer. 254: 4, 42–51.
Wong, C. F. and McCammon, J. A. (1986) To be submitted.
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Wong, C.F., McCammon, J.A. (1987). Thermodynamics of Enzyme Folding and Activity: Theory and Experiment. In: Ehrenberg, A., Rigler, R., Gräslund, A., Nilsson, L. (eds) Structure, Dynamics and Function of Biomolecules. Springer Series in Biophysics, vol 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71705-5_12
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DOI: https://doi.org/10.1007/978-3-642-71705-5_12
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