Effects of Pantethine on Lipid Metabolism in Isolated Rat Hepatocytes
Pantethine is the disulfide form of pantetheine the natural precursor of coenzyme A and of the prosthetic group of fatty acid synthetase. Interest in pantethine has increased recently as its lipid-lowering effects were demonstrated in laboratory animals (Shi-nomiya et al. 1980; Tomikawa et al. 1982) and in humans (Maggi et al. 1982; Avogaro et al. 1983; Gaddi et al. 1984). Since the mechanism of these effects is still unknown, we studied the modifications induced by pantethine on lipid metabolism in rat hepatocytes using either radioactive mevalonolactone (MVL) or acetate as the labeled substrate.
KeywordsCholesterol Dimethyl Disulfide Choles Squalene
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