Abstract
The hypocholesterolemic activity of vegetable proteins, particularly from soybean, was suggested early this century from animal studies (Ignatowski 1909; Meeker and Kesten 1940). In more recent years, several authors have demonstrated that the substitution of animal proteins with soybean proteins in the diet significantly reduces plasma cholesterol levels both in experimental animals (Terpstra et al. 1984) and in man (Sirtori et al. 1977). The soybean protein diet appears to be an effective alternative to drug treatments in adult type II hypercholesterolemic patients (Sirtori et al. 1977; Descovich et al. 1980), the activity being independent of dietary cholesterol and only partially influenced by the P/S ratio (Sirtori et al. 1979).
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References
Descovich GC, Ceredi C, Gaddi et al. (1980) Multicenter study of soybean protein diet for outpatient hypercholesterolaemic patients. Lancet ii:709–712
Fumagalli R, Paoletti R, Howard AN (1978) Hypocholesterolemic effect of soya. Life Sci 22:947–952
Fumagalli R, Soleri L, Farina R et al. (1982) Fecal colesterol excretion studies in type II hypercholesterolemic patients treated with the soybean protein diet. Atherosclerosis 43:341–352
Gaddi A, Descovich GC, Noseda G et al. (1987) Hypercholesterolaemia treated by soybean protein diet. Arch Dis Childh 62:274–278
Gibney MJ, Kritchevsky D (1983) Animal and vegetable proteins in lipid metabolism and atherosclerosis. Liss, New York
Huff MW, Carroll KK (1980) Effect of the dietary protein on turnover, oxidation and absorption of cholesterol and on steroid oxidation in rabbits. J Lipid Res 21:546–558
Ignatowski A (1909) Über die Wirkung des tierischen Eiweißes auf die Aorta und die parenchymatosen Organe der Kaninchen. Virchows Arch 198:248–270
Kim DN, Lee KT, Reiner JM et al. (1978) Effect of a soy product on serum and tissue cholesterol concentrations in swine fed high-fat, high-cholesterol diets. Exp Mol Pathol 29:385–399
Kovanen PT, Brown MS, Goldstein JL (1979) Increased binding of low density lipoprotein to liver membranes from rats treated with 17 α-ethinyl estradiol. J Biol Chem 254:11367–11373
Lovati MR, Allievi L, Sirtori CR (1985) Accelerated early catabolism of very low density lipoproteins in rats after dietary soy proteins. Atherosclerosis 56:243–246
Meeker DR, Kesten HD (1940) Experimental atherosclerosis and high protein diets. Proc Soc Exp Biol Med 45:543–545
Meinertz H, Nilausen K, Faergeman O (1984) Effects of dietary soy protein and casein on plasma lipoproteins in normolipidemic subjects. Circulation 70:1161 (Abstr)
Redgrave TG (1984) Dietary proteins and atherosclerosis. Atherosclerosis 52:349
Sirtori CR, Agradi E, Conti F et al. (1977) Soybean protein diet in the treatment of type II hyperlipoproteinaemia. Lancet i:275–277
Sirtori CR, Gatti E, Mantero O et al. (1979) Clinical experience with the soybean protein diet in the treatment of hypercholesterolemia. Am J Clin Nutrit 92:1645–1658
Sirtori CR, Galli G, Lovati MR et al. (1984) Effects of dietary proteins on the regulation of liver lipoprotein receptors in rats. J Nutrit 114:1493–1500
Sirtori CR, Zucchi-Dentone C, Sirtori M et al. (1985) Cholesterol-lowering and HDL-raising properties of lecithinated soy proteins in type II hyperlipidemic patients. Ann Nutrit Metab 29:348–357
Terpstra AHM, Tintelen G van, West CE (1982) The hypocholesterolemic effect of dietary soy protein in rats. J Nutrit 112:810–817
Terpstra AHM, West CE, Fennis JTCM et al. (1984) Hypocholesterolemic effect of dietary soy protein versus casein in rhesus monkeys. Am J Clin Nutrit 39:1–7
Van Raaij JAM, Katan MB, West CE et al. (1982) Influence of diets containing casein, soy isolate and concentrate on serum cholesterol and lipoproteins in middle-aged volunteers. Am J Clin Nutrit 35:925–934
Widhalm K (1986) Effect of diet on serum lipids and lipoprotein in hyperlipoproteinemic children. In: Beynen AC (ed) Nutritional effects on cholesterol metabolism. Transmondial, Voorthuizen, pp 133–140
Zierenberg O, Assmann G, Schmitz G et al. (1981) Effect of polyenephosphatidylcholine on cholesterol uptake by human high density lipoprotein. Atherosclerosis 39:527–542
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© 1987 Springer-Verlag Berlin Heidelberg
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Sirtori, C.R., Canavesi, A., Manzoni, C., Lovati, M.R. (1987). Dietary and Biochemical Studies with Textured Soy Proteins. In: Paoletti, R., Kritchevsky, D., Holmes, W.L. (eds) Drugs Affecting Lipid Metabolism. Proceedings in Life Sciences. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71702-4_32
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DOI: https://doi.org/10.1007/978-3-642-71702-4_32
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