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Suppressors of RAS Function in Saccharomyces cerevisiae

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Cell Cycle and Oncogenes

Abstract

The yeast Saccharomyces cerevisiae contains at least three genes which share homology with members of the ras oncogene family (6,7,12,23). YPT, on chromosome VI, shares about 40% homology with mammalian ras in the first 160 amino acids. RAS1 and RAS2 on chromosome XV and XIV respectively, are over 60% homologous with ras in the same region. Genetic analysis of these genes reveals that YPT and RAS1 and RAS2 constitute essential functions. Yeast cells lacking functional RAS1 and RAS2 genes are inviable (17,28); YPT fails to complement the mutations in RAS1 and RAS2 and therefore encodes a separate function (Gallwitz et al. Chap. II 8, this Vol.).

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Authors and Affiliations

  1. Department of Biology/G5, University of Pennsylvania, Philadelphia, Pennsylvania, 19104, USA

    R. B. Wilson

Authors
  1. K. Tatchell
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  2. J. F. Cannon
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  3. L. C. Robinson
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  4. R. B. Wilson
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Editor information

Editors and Affiliations

  1. Naturwissenschaftliche Fakultät III, Biologie und Vorklinische Medizin, Universitätsstraße 31, 8400, Regensburg, Germany

    Widmar Tanner

  2. Physiologisch-Chemisches Institut I, Universität Marburg, Emil-Mannkopff-Straße 1, 3550, Marburg, Germany

    Dieter Gallwitz

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© 1986 Springer-Verlag Berlin Heidelberg

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Tatchell, K., Cannon, J.F., Robinson, L.C., Wilson, R.B. (1986). Suppressors of RAS Function in Saccharomyces cerevisiae . In: Tanner, W., Gallwitz, D. (eds) Cell Cycle and Oncogenes. Colloquium der Gesellschaft für Biologische Chemie 10.–12. April 1986 in Mosbach/Baden, vol 37. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71686-7_13

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  • DOI: https://doi.org/10.1007/978-3-642-71686-7_13

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-71688-1

  • Online ISBN: 978-3-642-71686-7

  • eBook Packages: Springer Book Archive

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