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Arenaviruses pp 89–113Cite as

Pathology and Pathogenesis of Arenavirus Infections

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Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 133))

Abstract

In systemic virus infections, such as the arenavirus hemorrhagic fevers, pathologic and histopathologic examinations often contribute to the initial understanding of the nature of the disease, but definition of pathogenic mechanisms requires the addition of complementary techniques and experimental approaches – usually in animal models. The commonality of pathologic and histopathologic findings in cases of fatal arenavirus hemorrhagic fever suggests some common pathogenic mechanisms, but the differences reinforce the need for comprehensive study of each disease in naturally infected humans and in experimental animal models that mimic human infections.

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Author information

Authors and Affiliations

  1. Department of Pathology, The Medical School, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27514, USA

    D. H. Walker

  2. Division of Viral Diseases, Centers for Disease Control, Atlanta, GA, 30333, USA

    F. A. Murphy

Authors
  1. D. H. Walker
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  2. F. A. Murphy
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Editors and Affiliations

  1. Department of Immunology, Scripps Clinic and Research Foundation, 10666 North Torrey Pines Road, La Jolla, California, 92037, USA

    Michael B. A. Oldstone M.D.

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© 1987 Springer-Verlag Berlin · Heidelberg

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Walker, D.H., Murphy, F.A. (1987). Pathology and Pathogenesis of Arenavirus Infections. In: Oldstone, M.B.A. (eds) Arenaviruses. Current Topics in Microbiology and Immunology, vol 133. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71683-6_7

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  • DOI: https://doi.org/10.1007/978-3-642-71683-6_7

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  • Print ISBN: 978-3-642-71685-0

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