The Arenaviruses — An Introduction

  • M. B. A. Oldstone
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 133)


Viruses are generally studied either because they cause significant human, animal or plant disease or for their utility as materials to probe a basic phenomenon in biology, chemistry, genetics or molecular biology. Arenaviruses are unusually interesting in that they occupy both of these categories.


Lymphocytic Choriomeningitis Lassa Fever Lymphocytic Choriomeningitis Virus Lassa Virus LCMV Infection 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Cole GA, Prendergast RA, Henney CS (1973) In vitro correlates of LCM virus-induced immune response. In: Lehmann-Grube F (ed) Lymphocytic Choriomeningitis Virus and Other Arenaviruses. Springer, Berlin Heidelberg New YorkGoogle Scholar
  2. Grimwood BG (1985) Viral contamination of a subline of Toxoplasma gondii RH. Infect Immun 50: 917–918Google Scholar
  3. Grimwood BG, O’Connor G, Gaafar HA (1983) Toxofactor associated with Toxoplasma gondii infection is toxic and teratogenic to mice. Infect Immun 42: 1126–1135Google Scholar
  4. Hinman AR, Fraser DW, Douglas RG Jr, Bowen GS, Kraus AL, Winkler WG, Rhodes WW (1975) Outbreak of lymphocytic choriomeningitis virus infections in medical center personnel. Am J Epidemiol 101: 103–110PubMedGoogle Scholar
  5. Lehmann-Grube F (ed) (1973) Lymphocytic Choriomeningitis Virus and Other Arenaviruses. Springer, Berlin Heidelberg New YorkGoogle Scholar
  6. Marker O, Volkert M (1973) In vitro measurement of the time course of cellular immunity to LCM virus in mice. In: Lehmann-Grube F (ed) Lymphocytic Choriomeningitis Virus and Other Arenaviruses. Springer, Berlin Heidelberg New YorkGoogle Scholar
  7. Oldstone MBA (1975) Virus neutralization and virus-induced immune complex disease: Virus-antibody union resulting in immunoprotection or immunologic injury - two different sides of the same coin. In: Progress in Medical Virology. Karger, BaselGoogle Scholar
  8. Oldstone MBA (1984) Virus can alter cell function without causing cell pathology: Disordered function leads to imbalance of homeostasis and disease. In: Notking AL, Oldstone MBA (eds) Concepts in Viral Pathogenesis. Springer, New YorkGoogle Scholar
  9. Oldstone MBA, Dixon FJ (1969) Pathogenesis of chronic disease associated with persistent lymphocytic choriomeningitis viral infection. I. Relationship of antibody production to disease in neonatally infected mice. J Exp Med 129: 483–505Google Scholar
  10. Oldstone MBA, Peters CJ (1978) Arenavirus infections of the nervous system. In: Handbook of Clinical Neurology. North-Holland, AmsterdamGoogle Scholar
  11. Oldstone MBA, Sinha YN, Blount P, Tishon A, Rodriguez M, von Wedel R, Lampert PW (1982) Virus-induced alterations in homeostasis: Alterations in differentiated functions of infected cells in vivo. Science 218: 1125–1127Google Scholar
  12. Rowe WP (1954) Research Report NM 005 048.14. 01. Nav Med Res Inst, Bethesda, MarylandGoogle Scholar
  13. Rowe WP, Murphy FA, Bergold GH, Casals J, Hotchin J, Johnson KM, Lehmann-Grube F, Mims CA, Traub E, Webb PA (1970) Notes Arenaviruses: Proposed name for a newly defined virus group. J Virol 5: 651–652Google Scholar
  14. Van der Zeijst BAM, Bleumink N, Crawford LV, Swyryd EA, Stark GR (1983a) Viral proteins and RNAs in BHK cells persistently infected by lymphocytic choriomeningitis virus. J Virol 48: 262–270Google Scholar
  15. Van der Zeijst BAM, Noyes BE, Mirault M-E, Parker B, Osterhaus ADME, Swyryd EA, Bleumink N, Horzinek MC, Stark GR ( 1983 b) Persistent infection of some standard cell lines by lymphocytic choriomeningitis virus: Transmission of infection by an intracellular agent. J Virol 48: 249–261Google Scholar
  16. World Health Organization (1975) International Symposium on Arenavirus Infections of Public Health Importance. Bull WHO 52:Nos. 4, 5, 6Google Scholar
  17. Zinkernagel RM, Doherty PC (1974) Immunological surveillance against altered self-components by sensitized T lymphocytes in lymphocytic choriomeningitis. Nature (London) 251: 547–548CrossRefGoogle Scholar
  18. Zinkernagel RM, Doherty PC (1979) MHC-restricted cytotoxic T cells: Studies on the biological role of polymorphic major transplantation antigens determining T-cell restriction specificity, function, and responsiveness. Adv Immunol 27: 51–177PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin · Heidelberg 1987

Authors and Affiliations

  • M. B. A. Oldstone
    • 1
  1. 1.Department of ImmunologyScripps Clinic and Research FoundationLa JollaUSA

Personalised recommendations