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Radioligand Labelling of Nicotinic Receptors in Mammalian Brain

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Nicotinic Acetylcholine Receptor

Part of the book series: NATO ASI Series ((ASIH,volume 3))

Abstract

Nicotine clearly exerts many of its actions in the brain and spinal cord by acting at receptors, a conclusion drawn from biochemical (Chesselet, 1984), electrophysiological (Krnjevic, 1975), and behavioural (Romano et al, 1981; Clarke and Kumar, 1983) studies. Nevertheless, the pharmacological nature of these receptors is still a matter of debate; in particular, the extent of similarity between central and peripheral nicotinic receptors has been questioned. This chapter attempts to categorise the binding sites of nicotinic radioligands in mammalian brain and to examine whether such sites represent pharmacological sites of action for nicotine and acetylcholine.

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Author information

Authors and Affiliations

  1. Kinsmen Laboratory of Neurological Research Department of Psychiatry, University of British Columbia, Vancouver, V6T 1W5, Canada

    Paul B. S. Clarke

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  1. Paul B. S. Clarke
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Editor information

Editors and Affiliations

  1. Max-Planck-Institut für Ernährungsphysiologie, Rheinlanddamm 201, D-4600, Dortmund, Germany

    Alfred Maelicke

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© 1986 Springer-Verlag Berlin Heidelberg

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Clarke, P.B.S. (1986). Radioligand Labelling of Nicotinic Receptors in Mammalian Brain. In: Maelicke, A. (eds) Nicotinic Acetylcholine Receptor. NATO ASI Series, vol 3. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71649-2_28

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  • DOI: https://doi.org/10.1007/978-3-642-71649-2_28

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-71651-5

  • Online ISBN: 978-3-642-71649-2

  • eBook Packages: Springer Book Archive

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