Skip to main content
SpringerLink
Log in

Hormonrezeptoren

  • Chapter
Book cover Gynäkologische Endokrinologie

Zusammenfassung

Hormone sind an der Steuerung biologischer Vorgänge beteiligt, indem sie Informationen an ihr entsprechendes Erfolgsorgan weitergeben und in diesem zellspezifische Wirkungen veranlassen. Da die Hormone nach ihrer Synthese in den Blutkreislauf abgegeben werden und im gesamten Körper zirkulieren, müssen sie von ihren Erfolgsorganen erkannt und aufgenommen werden. Diese Aufgabe übernehmen die sog. Hormonrezeptoren, die sich durch folgende Eigenschaften auszeichnen:

  • Hohe Spezifität des Rezeptors zu dem entsprechenden Hormon, um eine Unterscheidung von anderen zirkulierenden Hormonen zu ermöglichen.

  • Hohe Affinität zum Hormon, da die physiologischen Hormonkonzentrationen im Serum niedrig sind.

  • Rezeptoren sollen nur in Geweben vorkommen, die auf das Hormon mit einer entsprechenden biologischen Wirkung ansprechen.

  • Die Hormonrezeptorbindung muß reversibel sein, um die biologische Wirkung beenden zu können.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  • Allegra JC, Lippman ME, Simon EB, Thompson EB, Barlock A, Green L, Huff KK, Do MMTC, Aitken SC, Warren R (1979) Association between steroid hormone receptor status and disease–free interval in breast cancer. Cancer Treat Rep 63: 1271–1277

    PubMed  CAS  Google Scholar 

  • Beatson GT (1896) On the treatment of inoperable cases of carcinoma of the mamma: suggestions for a new method of treatment with illustrative cases. Lancet 2: 104–107

    Article  Google Scholar 

  • Bonadonna G, Valagusse P, Rossi A, Tancini G, Bajetta E, Marchini S, Veronesi U (1977) CMF adjuvant chemotherapy in operable breast cancer. In: Jones S, Salmon SS, Jones SE (eds.) Adjuvant therapy of cancer II. North Holland, Amsterdam, pp 83–94

    Google Scholar 

  • Catt KJ, Dufau ML (1979) Peptide hormone receptors. Ann Rev Physiol 39: 529–557

    Article  Google Scholar 

  • Catt KJ, Dufau ML (1981) Hormone action: Control of target cell function by peptide, thyroid, and steroid hormones. In: Felig P, Baxter JD, Broodus AE, Frohman LA (eds) Endocrinology and metabolism. McGraw-Hill, New York, pp 61–106

    Google Scholar 

  • Cole MP, Jones CTA, Todd IDH (1971) A new anti-oestrogenic agent in late breast cancer. Brit J Cancer 25: 270–275

    Article  PubMed  CAS  Google Scholar 

  • EORTC–Breast Cancer Cooperative Group (1973) Standards for the assessment of estrogen receptors in human breast cancer. Eur J Cancer 9: 379–381

    Google Scholar 

  • EORTC–Breast Cancer Cooperative Group (1980) Revision of the standards for the assessment of hormone receptors in human breast cancer. Eur J Cancer 16: 1513–1515

    Google Scholar 

  • Fang S, Anderson KM, Liao S (1969) Receptor proteins for androgens: on the role of specific proteins in selective retention of 17β-hydroxy-5α-androstan-3-one by rat ventral prostate in vivo and in vitro. J Biol Chem 244: 6584–6595

    PubMed  CAS  Google Scholar 

  • Folca PJ, Glascock RF, Irvine WT (1961) Studies with tritium-labeled hexoestrol in advanced breast cancer. Lancet 2: 796–798

    Article  PubMed  CAS  Google Scholar 

  • Fox LL, Redenilk G, Boskevitch P, Baulieu EE, Richard-Foy H (1976) Production and detection of antibodies against the estrogen receptor from calf uterine cytosol. FEBS Lett 63: 71–76

    Article  PubMed  CAS  Google Scholar 

  • Glascock RF, Hoeckstra WG (1959) Selective accumulation of tritium labeled hexoestrol by the reproductive organs of immature female goats and sheep. Biochem J 72: 673–682

    PubMed  CAS  Google Scholar 

  • Greene GL, Fitch FW, Jensen EV (1980) Monoclonal antibodies to estrophilin: probes for the study of estrogen receptors. Proc Natl Acad Sci USA 77: 157–161

    Article  PubMed  CAS  Google Scholar 

  • Haddow A, Watkinson JM, Patterson E (1944) Influence of synthetic estrogens upon advanced malignant disease. Br Med J 2: 393–398

    Article  PubMed  CAS  Google Scholar 

  • Hähnel R, Woodings T, Vivian AB (1979) Prognostic value of estrogen receptor in primary breast cancer. Cancer 44: 671–675

    Article  PubMed  Google Scholar 

  • Högel B, Jawny J, Eiermann W (1982) Fluoreszenz-mikroskopischer Nachweis von Ostrogen-and Gestagenrezeptoren im Mammakarzinom. Tumor Diagnostik 3: 6–8

    Google Scholar 

  • Huggins C, Bergenstal DM (1952) Inhibition of human mammary and prostatic cancer by adrenalectomy. Cancer Res 12: 134–141

    PubMed  CAS  Google Scholar 

  • Huggins C, Hodges CV (1941) Studies on prostatic cancer. I. The effect of castration, of estrogen and of androgen injection on serum phosphatases in metastatic carcinoma of the prostata. Cancer Res 1: 293–297

    CAS  Google Scholar 

  • Huggins C., Stevens RE, Hodges CV (1941) Studies on prostatic cancer. II. The effects of castration on advanced carcinoma of the prostata gland. Arch Surg 43: 209–223

    CAS  Google Scholar 

  • Jensen EV (1981) Hormone dependency of breast cancer. Cancer 47: 2319–2326

    Article  PubMed  CAS  Google Scholar 

  • Jensen EV, De Sombre ER (1973) Estrogen-receptor interaction. Science 182: 126–134

    Article  PubMed  CAS  Google Scholar 

  • Jensen EV, Jacobson HJ (1962) Basic guides to the mechanism of estrogenic action. Recent Prog Horm Res 18: 387–414

    CAS  Google Scholar 

  • Kaufmann M, Klinga K (1982) Mögliche prognostische Kriterien zur Therapieverbesserung beim primären Mammakarzinom. Geburtshilfe Frauenheilkd 42: 501–509

    Article  PubMed  CAS  Google Scholar 

  • Kennedy BJ (1962) Massive estrogen administration in premenopausal women with metastatic breast cancer. Cancer 15: 641–648

    Article  PubMed  CAS  Google Scholar 

  • Klinga K, Kaufmann M, Runnebaum B, Kubli F (1982a) Distribution of estrogen and progesterone receptors on primary tumor and lymph nodes in individual patients with breast cancer. Oncology 39: 337–339

    Article  PubMed  CAS  Google Scholar 

  • Klinga K, Kaufmann M, Runnebaum B, Kubli F (1982b) Steroidhormon-rezeptoren beim Mammakarzinom. Dtsch Med Wochenschr 107: 313–315

    Article  PubMed  CAS  Google Scholar 

  • Klinga K, Kaufmann M, Runnebaum B, Kubli F (1982c) Abhängigkeit der Ostrogen-and Progesteronrezeptoren vom Alter, Menopausenzustand and Lymphknotenbefall sowie Verteilung der Rezeptoren im Primärtumor and Lymphknoten. In: Jonat W, Maass H (Hrsg) Steroidhormonrezeptoren im Karzinomgewebe. Enke, Stuttgart, S 90–94

    Google Scholar 

  • Kuhn RW, Schrader WT, Smith RG, O’Malley BW (1975) Progesterone binding components of chick oviduct. X. Purification by affinity chromatography. J Biol Chem 250: 4220–4228

    PubMed  CAS  Google Scholar 

  • Lippman ME, Bolan G (1975) Oestrogen-responsive human breast cancer in longterm tissue culture. Nature (London) 256: 592–593

    Article  CAS  Google Scholar 

  • Maass H, Jonat W (1979) Steroidrezeptoren in Mammakarzinomen. Bericht über ein Consensus-Meeting im NIH, Bethesda. Geburtshilfe Frauenheilkd 39: 761–764

    Google Scholar 

  • Mainwaring WIP (1969) A soluble androgen receptor in the cytoplasma of rat prostata. J Endocrinol 45: 531–541

    Article  PubMed  CAS  Google Scholar 

  • Milgrom E, Baulieu EE (1970) Progesterone in uterus and plasma. I. Binding in rat uterus 105,000g supernatant. Endocrinology 87: 276–287

    Article  PubMed  CAS  Google Scholar 

  • Munck A, Brinck-Johnsen T (1968) Specific and nonspecific physicochemical interactions of glucocorticoids and related steroids with rat thymus cells in vitro. J Biol Chem 243: 5556–5565

    PubMed  CAS  Google Scholar 

  • Nathamon JT (1952) Clinical investigative experience with steroid hormones in breast cancer. Cancer 5: 754–762

    Article  Google Scholar 

  • O’Malley BW, Sherman MR, Toft DO (1970) Progesterone „receptors“ in the cytoplasm and nucleus of chick oviduct target tissue. Proc Natl Acad Sci USA 67: 501–508

    Article  PubMed  Google Scholar 

  • Pannutti F (1979) Die hochdosierte Gestagenbehandlung in der Therapie des fortgeschrittenen Mammakarzinoms. Onkologie 2: 54–60

    Article  Google Scholar 

  • Pertuschek LP, Tobin EM, Gaetjens E, Carter AC, Degensheim GA, Bloom ND, Brigati DJ (1980) Histochemical assay of estrogen and progesterone receptors in breast cancer. Cancer 46: 2896–2901

    Article  Google Scholar 

  • Philibert D, Raynaud JP (1974) Binding of progesterone and R 5020, a highly potent progestin, to human endometrium and myometrium. Contraception 10: 457–466

    Article  PubMed  CAS  Google Scholar 

  • Press MF, Greene GL (1984) Methods in laboratory investigation: an immunocytochemical method for demonstrating estrogen receptor in human uterus using monoclonal antibodies to humen estrophilin. Lab Invest 50: 480–486

    PubMed  CAS  Google Scholar 

  • Puca GA, Silca V, Nola F (1974) Identification of a high affinity nuclear acceptor site for estrogen receptor of calf uterus. Proc Natl Acad Sci USA 71: 979–983

    Article  PubMed  CAS  Google Scholar 

  • Scatchard G (1949) The attractions of proteins for small molecules and ions. Ann NY Acad Sci 51: 660–672

    Article  CAS  Google Scholar 

  • Shiu RPC, Friesen HG (1974) Properties of a prolactin receptor from the rabbit mammary gland. Biochem J 140: 301–311

    PubMed  CAS  Google Scholar 

  • Sutherland EW, Robison GA (1966) Metabolic effects of catecholamines. A. The role of cyclic3’-5’-AMP in responses to catecholamines and other hormones. Pharmacol Rev 18: 145–161

    PubMed  CAS  Google Scholar 

  • Toft D, Gorski J (1966) A receptor molecule for estrogens. Isolation from the rat uterus and preliminary characterization. Proc Natl. Acad Sci USA 55: 1574–1581

    Article  PubMed  CAS  Google Scholar 

  • Ward HWC (1973) Anti-oestrogen therapy for breast cancer. A trial of tamoxifen at two dose levels. Br Med J 1, 13–14

    Article  PubMed  CAS  Google Scholar 

  • Wittliff JL, Beatty BW, Baker DT, Savlov ED, Cooper RA (1977) Clinical significance of molecular forms of estrogen receptors in human breast cancer. In: Vermeulen A, Jungblut P, Klopper A (eds) Research on steroids VII. Elsevier, North Holland, Amsterdam, pp 393–403

    Google Scholar 

Download references

Authors
  1. K. Klinga
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. Kaufmann
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

Copyright information

© 1987 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Klinga, K., Kaufmann, M. (1987). Hormonrezeptoren. In: Gynäkologische Endokrinologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71568-6_2

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-71568-6_2

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-71569-3

  • Online ISBN: 978-3-642-71568-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation