Abstract
The chick oviduct is a particularly suitable system to study the molecular mechanisms regulating gene expression, because the synthesis of the major egg- white proteins (e.g. ovalbumin and conalbumin) can be modulated in the tubular gland cells by the administration and withdrawal of estrogens, progestins, glucocorticoids and androgens, each acting through a distinct hormone receptor (see Shepherd et al. 1980 and refs. therein). Following hormonal stimulation, there is an accumulation of the egg-white protein mRNAs, which results at least in part from an increased rate of transcription of the corresponding genes (see McKnight and Palmiter 1979 and refs. therein). Arrest of stimulation (withdrawal) leads to a cessation of synthesis of these mRNAs, which can be restimulated by administrations of anyone of the four steroid hormones.
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References
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© 1986 Springer-Verlag, Berlin Heidelberg
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Dierich, A., Gaub, M.P., Astinotti, D., Touitou, I., Le Pennec, J.P., Chambon, P. (1986). Regulation of the Chicken Ovalbumin Gene Expression by Steroid Hormones in a Transient Assay. In: Peters, R., Trendelenburg, M. (eds) Nucleocytoplasmic Transport. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71565-5_21
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DOI: https://doi.org/10.1007/978-3-642-71565-5_21
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