Summary
Exon 1 deleted c-myc RNAs found in some mouse plasma cell tumors (Piechaczyk et al., 1985) and Burkitt’s lymphomas (Eick et al., 1985) are more stable than their normal counterparts in control cells. In this paper we extend our original observations to other B cell and we prove that the structural modification of c-myc RNA is responsible for its stabilization. However, we also show that exon 1 by itself does not account for the extreme instability of normal c-myc RNAs. Finally our results suggest that abnormal c-myc transcripts, while always stabilized in the cytoplasm, may sometimes be more actively degraded in the nucleus than normal ones in reference cell lines.
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© 1986 Springer-Verlag Berlin · Heidelberg
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Piechaczyk, M. et al. (1986). Altered c-myc RNA Metabolism in Burkitt’s Lymphomas and Mouse Plasmacytomas. In: Melchers, F., Potter, M. (eds) Mechanisms in B-Cell Neoplasia. Current Topics in Microbiology and Immunology, vol 132. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71562-4_49
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DOI: https://doi.org/10.1007/978-3-642-71562-4_49
Publisher Name: Springer, Berlin, Heidelberg
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