Molecular Analysis of myc Gene Mutants
The myc gene was first Identified as a specific cellular sequence In the avian acute leukemia virus MC29 (Mellon et al., 1978; Roussel et al., 1979). Analysis of this virus has led to an extensive characterization of this sequence, the cellular homologue from which It was derived, and the gene product encoded by the virus (Hayman, 1983). The myc gene as found In MC29 Is closely related to the cellular sequence, c-myc (Watson et al., 1983). Only nine nucleotide changes are seen between MC29 v-myc and c-myc giving rise to seven amino acid changes. In addition v-myc contains ten base pairs of coding sequence at the 5’ end not found In c-myc The c-myc gene has three exons (two of which are coding exons) and two introns.
KeywordsLymphoma Leukemia Recombination Polypeptide Carboxy
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