Abstract
In both Burkitt’s lymphomas and murine plasmacytomas there are specific disease-associated chromosomal translocations that bring into contiguity one of the immunoglobulin gene loci with the c-myc proto-oncogene (Klein 1983). These specific chromosomal translocations can occur 5′ or 3′ of the c-myc oncogene and are believed to cause deregulation of expression of c-myc. This is supported by the fact that in these tumors only the c-myc gene involved in the translocation is expressed (Taub 1984).
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© 1986 Springer-Verlag Berlin · Heidelberg
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Hollis, G.F., Gazdar, A.F., Kirsch, I.R. (1986). DNA Rearrangement and Expression of the c-myc Gene in a Human Myeloma. In: Melchers, F., Potter, M. (eds) Mechanisms in B-Cell Neoplasia. Current Topics in Microbiology and Immunology, vol 132. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71562-4_33
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DOI: https://doi.org/10.1007/978-3-642-71562-4_33
Publisher Name: Springer, Berlin, Heidelberg
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