Abstract
Transferrin receptor (TfR) expression in lymphoid cells is normally regulated by interaction of tissue-specific growth factors with their receptors (Neekers and Cossman 1983, Neekers et al. 1984). Malignant transformation of T and B lymphocytes generally leads to constitutive expression of TfR (Neekers 1985). Mouse plasmacytomas are an example of terminally differentiated B cells which continue to proliferate in an uncontrolled manner and constitutively express TfR in vivo. However, in vitro growth of most plasmacytomas requires the presence of a macrophage-derived growth factor (plasmacytoma growth factor, PCT-GF) described elsewhere in this volume (Nordan et al.; see also Nordan and Potter 1986). In this report we characterize the relationship between PCT-GF and TfR in plasmacytoma cell lines and describe a TfR mRNA species uniquely found in mouse plasmacytomas.
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© 1986 Springer-Verlag Berlin · Heidelberg
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Neckers, L.M., Nordan, R., Bauer, S., Potter, M. (1986). Studies on Transferrin Receptor Expression in Mouse Plasmacytoma Cells. In: Melchers, F., Potter, M. (eds) Mechanisms in B-Cell Neoplasia. Current Topics in Microbiology and Immunology, vol 132. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71562-4_20
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DOI: https://doi.org/10.1007/978-3-642-71562-4_20
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