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Role of the LFA-1 Molecule in B Cell Differentiation

  • Gail Abendroth Bishop
  • Geoffrey Haughton
Conference paper
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 132)

Abstract

The lymphocyte function-associated antigen-1 (LFA-1) was first identified as a T cell surface antigen, and antibodies to LFA-1 have been shown to inhibit responses of T cells to antigen and/or major histocompatibility complex (MHC) molecules (Springer 1982, Krensky 1983, Ware 1983, Collins 1984, Krensky 1984, Golde 1985, Naquet 1985). However, LFA-1 molecules are also present on the surface of B cells (Davignon 1981), and the possible functional role played by B cell LFA-1 has received little attention.

Keywords

Major Histocompatibility Complex Phorbol Myristate Acetate Tissue Culture Supernatant Differentiative Signal 30C7 Dilution 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin · Heidelberg 1986

Authors and Affiliations

  • Gail Abendroth Bishop
    • 1
  • Geoffrey Haughton
    • 1
  1. 1.Department of Microbiology and Immunology and The Lineberger Cancer Research CenterThe University of North Carolina at Chapel HillChapel HillUSA

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