c-Myc-Induced Lymphomagenesis in Transgenic Mice and the Role of the Pvt-1 Locus in Lymphoid Neoplasia
Dysregulated expression of the c-myc proto-oncogene has been strongly implicated in lymphoid neoplasia, as reviewed by Leder et al (1984), Klein and Klein (1985), Adams and Cory (1985) and Cory (1986). In plasmacytomas of the mouse and Burkitt lymphomas of man, a predominant form of chromosomal translocation couples the c-myc gene to the IgH constant region locus, presumably bringing c-myc under the control of factors that regulate immunoglobulin expression. In someT lymphomas induced by retroviruses, a provirus has inserted near c-myc (e. g. Corcoran et al 1984). Thus strong circumstantial evidence links altired regulation of myc with lymphomagenesis. Typically, the alterations occur in the immediate vicinity of c-myc, but another class may involve long-range effects within the myc-bearing chromosome, as exemplified by the changes within the pvt-1 locus discussed later.
KeywordsBurkitt Lymphoma Mouse Mammary Tumor Virus Variant Translocation Strong Circumstantial Evidence Proviral Integration Site
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