Effects of Dopamine-Rich Grafts on Sensorimotor Impairments in Dopamine-Depleted Rats

  • S. B. Dunnett
  • A. Björklund
Conference paper
Part of the Advances in Applied Neurological Sciences book series (NEUROLOGICAL, volume 4)


Following the description, in the early 1970s, of reliable techniques for the transplantation of neural tissues to the brains of experimental mammals [10, 34, 41], research effort focused on the use of grafts, primarily at the anatomical level, to study developmental processes and regenerative potential in the CNS [2, 27, 28]. However, once it became apparent that neural grafts can survive and grow in the brain, the question of the functional contribution of such grafts was raised. In particular, could it be possible to reconstruct or replace damaged neurones by transplantation in a manner sufficient to ameliorate impairments or restore lost functions disrupted by neurological lesions? In 1979, two reports appeared [3, 35] which demonstrated that grafts of embryonic dopamine (DA)-rich tissue to the forebrains of rats could reverse motor impairments associated with DA-depleting lesions.


Lateral Hypothalamus Sensorimotor Impairment Comp Physiol Psychol Suspension Graft Ventrolateral Striatum 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • S. B. Dunnett
    • 1
  • A. Björklund
    • 2
  1. 1.Department of Experimental PsychologyCambridgeUK
  2. 2.Department of HistologyLundSweden

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