Abstract
We are engaged in a molecular biological analysis of the presumptive role of hepatitis B virus (HBV) in the pathogenesis of human hepatocellular carcinoma. This article is mainly about our own results obtained with the PLC/PRF/5 cell line, but I will also try to put our data in a more general context by including results from other groups, some of which were presented at a recent conference on the molecular biology by hepadnaviruses held in Cold Spring Harbor in May 1985.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Freytag von Loringhoven A, KochS, Hofschneider PH, KoshyR: Co-transcribed 3′ host sequences augment expression of integrated hepatitis B virus DNA. EMBO J. 4 (1985) 249–255
Koch S, Freytag von Loringhoven A, Hofschneider PH, Koshy R: Amplification and rear-rangement in hepatoma cell DNA associated with integrated hepatitis B virus DNA. EMBO J. 3 (1984) 2185–2189
Koch S, Freytag von Loringhoven A, Kahmann R, Hofschneider PH, Koshy R: The genetic organization of hepatitis B virus DNA in the human hepatoma cell line PLC/PRF/5. Nucl. Acids Res. 12 (1984) 6871–6886
Koshy R, Koch S, Freytag von Loringhoven A, Kahmann R, Murray K, Hofschneider PH: Integration of hepatitis B virus DNA: evidence for integration in the single-stranded gap. Cell 34 (1983) 215–223
Marquardt O, Freytag von Loringhoven A, FrösnerG: Expression of hepatitis B virus core antigen is induced in human hepatoma cells by their growth in nude mice. J. Gen. Virol. 65 (1984) 1443–1448
Marquardt O, Zaslavsky V, Hofschneider PH: Evidence for non-chromosomal hepatitis B virus surface (HBsAg-) and core antigen (HBcAg-) DNA sequences in a human hepatoma cell line. J. Gen. Virol 61 (1982) 105–109
Moriarty A, Alexander H, Lerner R, Thornton G: Antibodies to peptides detect new hepatitis B antigen: serological correlation with hepatocellular carcinoma. Science 227 (1985) 429–432
Ogston C, Jonak G, Rogler C, Astrin S, Summers J: Cloning and structural analysis of integrated woodchuck hepatitis virus sequences from hepatocellular carcinomas of wood- chucks. Cell 29 (1982) 385–394
Ziemer M, Garcia P, Shaul Y, Rutter W: Sequence of hepatitis B virus DNA incorporated into the genome of a human hepatoma cell line. J. Virol. 53 (1985) 885–892
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1987 Springer-Verlag
About this chapter
Cite this chapter
Freytag von Loringhoven, A. (1987). Hepatitis B Virus Sequences and Their Expression in Human Hepatoma Cells. In: Wagner, G., You-Hui, Z. (eds) Cancer of the Liver, Esophagus, and Nasopharynx. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71510-5_8
Download citation
DOI: https://doi.org/10.1007/978-3-642-71510-5_8
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-16967-3
Online ISBN: 978-3-642-71510-5
eBook Packages: Springer Book Archive