Selenium as a Possible Chemopreventive Agent Against Cancer

  • Zhang You-Hui


Evidence has indicated that selenium as a trace element supplemented to a normal diet decreases tumor incidence in animals exposed to chemical carcinogens and in animals with a high tendency to develop spontaneous tumors. A striking example is that observed by Schrauzer and Ishmael [1] in which the incidence of mammary tumors afflicting 80% of aged C3H mice can be reduced to 10% by the long-term feeding of subtoxic levels of sodium selenite. This protective effect of selenium has naturally led people to think that selenium deficiency, on the other hand, would render the hosts susceptible to carcinogenic insults.


Spleen Cell Sodium Selenite Chemopreventive Agent Mixed Lymphocyte Culture Lewis Lung Cancer 
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  1. 1.
    Schrauzer GN, Ishmael D: Effects of selenium and arsenic on the genesis of spontaneous mammary tumors in inbred C3H mice. Ann Clin Lab Sci 4 (1974) 441–447PubMedGoogle Scholar
  2. 2.
    Yu SY, Chu YJ, Gong XL et al.: Biol Trace Element Res 7 (1985) 21–29CrossRefGoogle Scholar

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© Springer-Verlag 1987

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  • Zhang You-Hui

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