Abstract
Prostacyclin, or PGI2, is a powerful inhibitor of platelet aggregation, and has been used clinically to reduce platelet activity in thrombotic conditions. In addition to its anticoagulant effects, heparin also has a direct effect upon platelet function. Heparin increases platelet sensitivity to ADP and adrenaline, lowering the threshold concentrations of these agents which are required to induce aggregation [18]. Heparin has been reported to induce aggregation in washed platelets in the absence of standard agonists [4]. Inhibition of adenylate cyclase activity by heparin has been demonstrated in several biological systems, including rat hepatocytes [1], rat ovarian cell membranes [15], and human platelets [11]. Reduction of intraplatelet cyclic AMP may contribute to the enhancement of platelet aggregability by heparin.
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© 1987 Springer-Verlag, Berlin Heidelberg
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Machin, S.J., Yardumain, D.A., O’Flynn, K., Linch, D.C. (1987). Laboratory Investigations of Potential Heparin — Iloprost Interactions. In: Gryglewski, R.J., Stock, G. (eds) Prostacyclin and Its Stable Analogue Iloprost. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71499-3_9
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DOI: https://doi.org/10.1007/978-3-642-71499-3_9
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