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Desensitization of Iloprost or Prostacyclin Responsiveness

  • J. MacDermot
  • U. Alt
  • P. J. Leigh
  • P. K. Morris
  • A. J. Wilkins
  • M. J. Brown
  • I. A. Blair
Conference paper

Abstract

The biological effects of prostacyclin (PGI2) are mediated by activation of adenylate cyclase. In most respects the biochemical events that accompany occupation by agonist of specific PGI2 receptors on “target tissues” are similar to those described for numerous other neurotransmitter and hormonal systems.

Keywords

Adenylate Cyclase Fractional Occupancy Royal Postgraduate Medical School Prostacyclin Receptor Nylate Cyclase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag, Berlin Heidelberg 1987

Authors and Affiliations

  • J. MacDermot
    • 1
  • U. Alt
    • 1
  • P. J. Leigh
    • 1
  • P. K. Morris
    • 1
  • A. J. Wilkins
    • 1
  • M. J. Brown
    • 1
  • I. A. Blair
    • 1
  1. 1.Department of Clinical Pharmacology, Royal Postgraduate Medical SchoolUniversity of LondonUK

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