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Effects of Iloprost on Arrhythmias and Infarct Size in Rats After Coronary Artery Ligation

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Prostacyclin and Its Stable Analogue Iloprost

Abstract

Iloprost is a stable, orally active prostacyclin (PGI2) analogue with a pharmacologic profile and activity nearly identical to PGI2 [1,2]. Both PGI2 and Iloprost have been shown in a variety of experimental models to protect acutely ischemic myocardium from functional deterioration, cell enzyme leakage, and ventricular arrhythmias [3–5].

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References

  1. Schillinger E, Vorbriiggen H (1981) Ciloprost. Drugs Future 6: 676–677

    Google Scholar 

  2. Schillinger E, Vorbriiggen H (1983) Iloprost. Drugs Future 8: 977

    Google Scholar 

  3. Coker SJ, Parratt JR (1983) Prostacyclin - antiarrhythmic or arrhythmogenic? Comparison of the effects of intravenous and intracoronary prostacyclin and ZK 36 374 during coronary artery occlusion and reperfusion in anaesthetized greyhounds. J Cardiovasc Pharmacol 5: 557–567

    Article  PubMed  CAS  Google Scholar 

  4. Ogletree ML, Lefer AM, Smith BJ, Nicolaou KC (1979) Studies on the protective effect of prostacyclin in acute myocardial ischemia. Eur J Pharmacol 56: 95–103

    Article  PubMed  CAS  Google Scholar 

  5. Schror K, Ohlendorf R, Darius H (1981) Beneficial effects of a new carbacyclin derivative, ZK 36374, in acute myocardial ischemia. J Pharmacol Exp Ther 219: 243–249

    PubMed  CAS  Google Scholar 

  6. Jugdutt BI (1981) Prostaglandins in myocardial infarction: with emphasis on myocardial preservation. Prostaglandins Med 7: 109–123

    Article  PubMed  CAS  Google Scholar 

  7. Smith GU, Duncan GG (1981) A study of intravascular platelet aggregation by continuous platelet counting. Thromb Res 23: 275–288

    Article  PubMed  CAS  Google Scholar 

  8. Selye H, Bajusz E, Grasso S, Mendell P (1960) Simple techniques for the surgical occlusion of coronary vessels in the rat. Angiol 11: 398–407

    Article  CAS  Google Scholar 

  9. Bernauer W (1980) Effecs of glucocorticosteroids in rats with acute myocardial infarction. Arch Int Pharmacodyn 244: 86–99

    PubMed  CAS  Google Scholar 

  10. Reimer KA, Jennings RB (1984) Can we really quantitate myocardial cell injury? In: Hearse DJ, Yellon DM (eds) Therapeutic approaches to myocardial infarct size limitation. Raven, New York, pp 163–184

    Google Scholar 

  11. Krause W, Jakobs U, Schulze PE, Nieuweboer B, Hümpel M (1985) Development of anti-body-mediated extraction followed by GC/MS (antibody/GC/MS) and its application to Iloprost determination in plasma. Prostaglandins Leukotrienes Med 17: 167–182

    Article  CAS  Google Scholar 

  12. Braunwald E, Maroko PR (1974) The reduction of infarct size - an idea whose time (for testing) has come. Circulation 50: 206–209

    PubMed  CAS  Google Scholar 

  13. Johnston KM, McLeod BA, Walker MJA (1983) Effects of aspirin and prostacyclin on arrhythmias resulting from coronary-artery ligation and on infarct size. Br J Pharmacol 78:29– 37

    PubMed  CAS  Google Scholar 

  14. Jennings RB, Ganote GL (1974) Structural changes in myocardium during acute ischemia. Circ Res 34:111 156–III172

    Google Scholar 

  15. Reimer K, Jennings R (1979) The wavefront phenomenon of myocardial cell death. Ill: Transmural progression of necrosis within the framework of ischemic bed size (myocardium at risk) and collateral flow. Lab Invest 40: 633–641

    PubMed  CAS  Google Scholar 

  16. Schaper W (1979) Can infarct size be reduced? Pathophysiological considerations about the role of beta receptor blockade in the treatment of myocardial infarction. Herz Kreisl 11:463– 469

    Google Scholar 

  17. Kübler W, Doorey A (1985) Reduction of infarct size. An attractive concept: useful - or possible - in humans? Br Heart J 53: 5–8

    Article  PubMed  Google Scholar 

  18. Romson JL, Jolly SR, Lucchesi BR (1984) Protection of ischemic myocardium by pharmacologic manipulation of leukocyte function. Cardiovasc Rev Rep 5: 690–709

    Google Scholar 

  19. Smith III EF, Gallenkämper W, Beckmann R, Thomsen T, Mannesmann G, Schrör K (1984) Early and late administration of a PGI2-analogue, ZK 36374 (Iloprost): Effects on myocardial preservation, collateral blood flow and infarct size. Cardiovasc Res 18: 163–173

    Article  PubMed  CAS  Google Scholar 

  20. Schrör K, Darius H, Addicks K, Köster R, Smith III EF (1982) PGI2 prevents ischemia- induced alterations in cardiac catecholamines without influencing nerve-stimulation-in- duced catecholamine release in nonischemic conditions. J Cardiovasc Pharmacol 4:741– 748

    Article  PubMed  Google Scholar 

  21. Nayler WG, Purchase M, Dusting GJ (1984) Effect of prostacyclin infusion during low-flow ischemia in the isolated perfused rat heart. Basic Res Cardiol 79: 125–134

    Article  PubMed  CAS  Google Scholar 

  22. Thiemermann C, Steinhagen-Thiessen E, Schrör K (1984) Inhibition of oxygen-centered free radical formation by the stable prostacyclin-mimetic Iloprost (ZK 36374) in acute myocardial ischemia. J Cardiovasc Pharmacol 6: 365–366

    Article  PubMed  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Cardiovascular Pharmacology, Research Laboratories of Schering AG, Berlin, Germany

    B. Müller, B. Maaß, C.-S. Stürzebecher & W. Witt

Authors
  1. B. Müller
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  2. B. Maaß
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  3. C.-S. Stürzebecher
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  4. W. Witt
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Editor information

Editors and Affiliations

  1. Department of Pharmacology, Copernicus Academy of Medicine, 16 Grzegórzecka, 31531, Cracow, Poland

    R. J. Gryglewski

  2. Cardiovascular Pharmacology, Schering AG, Müllerstraße 170–178, 1000, Berlin 65, Germany

    G. Stock

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© 1987 Springer-Verlag, Berlin Heidelberg

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Müller, B., Maaß, B., Stürzebecher, CS., Witt, W. (1987). Effects of Iloprost on Arrhythmias and Infarct Size in Rats After Coronary Artery Ligation. In: Gryglewski, R.J., Stock, G. (eds) Prostacyclin and Its Stable Analogue Iloprost. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71499-3_21

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  • DOI: https://doi.org/10.1007/978-3-642-71499-3_21

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-71501-3

  • Online ISBN: 978-3-642-71499-3

  • eBook Packages: Springer Book Archive

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