Myocardial Ischemia: The Potential Therapeutic Role of Prostacyclin and Its Analogues

  • P. J. Simpson
  • B. R. Lucchesi


Prostacyclin (PGI2) and its stable analogues are potentially valuable therapeutic agents in at least three important cardiovascular disorders. By virtue of the vasodilatory properties of these agents and their ability to inhibit platelet activation by virtually all aggregating stimuli PGI2 analogues may be effective anti–thrombotic agents in vivo. Romson et al. [41] demonstrated that PGI2 infusion in the anesthetized dog was effective in preventing coronary artery thrombosis. Furthermore, administration of low dose PGI2 concomittantly with a phosphor–diesterase inhibitor, potentiated the antithrombotic effects of PGI2 without the decrease in blood pressure associated with higher doses of the prostanoid [43, 44].


Infarct Size Myocardial Infarct Size Acute Myocardial Ischemia Regional Myocardial Blood Flow Collateral Blood Flow 
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Copyright information

© Springer-Verlag, Berlin Heidelberg 1987

Authors and Affiliations

  • P. J. Simpson
    • 1
  • B. R. Lucchesi
    • 1
  1. 1.Medical School, Department of PharmacologyThe University of MichiganAnn ArborUSA

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