Effect of Iloprost (ZK 36374) on White Cell Behavior

  • J. J. F. Belch
  • A. Saniabadi
  • R. Dickson
  • R. D. Sturrock
  • C. D. Forbes

Abstract

Platelets, red cells and plasma constituents have long been recognized as being involved in the maintenance of blood flow and in the development of thrombosis following vessel damage. Little attention, however, has been paid to the possible contribution of the white blood cell. Recently epidemiological studies have noted that subjects at risk from developing ischemic events have had an elevation in the numbers of their white blood cells (WBCs). In addition, histopathological studies of ischemic tissue have shown adhesion and aggregation of WBCs to the endothelium, followed by migration and invasion of cells into the necrotic area. These WBC clumps may further impede blood flow, and release of noxious substances from the cell may contribute to further tissue damage. We have investigated some aspects of WBC behavior in patients with atherosclerotic and inflammatory vascular disease, and the results suggest that the patients have a general increase in WBC activity when compared to age and sex-matched controls, A drug which decreases this activity might therefore be useful in the management of arterial disease.

Keywords

Clay Formalin Migration Ischemia Superoxide 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Boyum A (1968) Isolation of mononuclear cells and granulocytes from blood. Scand J Clin Lab Invest 21 (97): 77–89Google Scholar
  2. 2.
    Craddock PR, White JG, Jacob HS (1978) Potentiation of complement ( C5a)-induced granulocyte aggregation by cytochalasin B. J Lab Clin Med 91: 490–499Google Scholar
  3. 3.
    Born GVR (1962) Aggregation of blood platelets by adenosine diphosphate and its reversal. Nature 194: 927–929PubMedCrossRefGoogle Scholar
  4. 4.
    Saniabadi AR, Lowe GDO, Belch JJF, Forbes CD, Prentice CRM, Barbanel JC (1983) The novel effect of a new prostacyclin analogue ZK 36 374 on the aggregation of human platelets in whole blood. Thromb Haemost 50 (3): 718–721PubMedGoogle Scholar
  5. 5.
    Ganstrom E, Kindahl H (1978) Radioimmunoassay of prostaglandins and thromboxanes. In: Frolich JC (ed) Advances in prostaglandin and thromboxane research, vol 5, Raven, New York, pp 119–127Google Scholar
  6. 6.
    Misra HP, Fridovich I (1977) Measurement of superoxide dismutase activity. Arch Biochem Biopley 181: 308–311CrossRefGoogle Scholar

Copyright information

© Springer-Verlag, Berlin Heidelberg 1987

Authors and Affiliations

  • J. J. F. Belch
    • 1
  • A. Saniabadi
    • 1
  • R. Dickson
    • 1
  • R. D. Sturrock
    • 1
  • C. D. Forbes
    • 1
  1. 1.Department of MedicineRoyal InfirmaryGlasgowUK

Personalised recommendations