Diuretika III pp 129-139 | Cite as

Diuretics and Magnesium Handling

  • J. H. Dirks
  • N. L. M. Wong
Conference paper


A discussion of diuretic action on magnesium excretion is usually preceded by a short review of overall homeostasis and renal handling of magnesium. Magnesium is the fourth most abundant cation in the human body and the second most common cation in the intracellular fluid next to potassium. The adult human body contains 21–28 g of magnesium [1]. The plasma magnesium concentration ranges from 0.7 to 1.0 mmol/liter in normal subjects. Approximately 2% of the total body magnesium is located in extracellular compartments. The major magnesium pool is almost exclusively intracellular; approximately 65% is found in the bone, 20% in the muscle and 11% in the nonmuscle soft tissue. Intracellular magnesium plays a vital role in many cell processes, including production and utilization of energy as the membrane bound Mg-activated adenosine triphosphatase [2, 3]. Extracellular magnesium is implicated in neuronal control, neuromuscular transmission and cardiovascular tone [4]. In man, approximately 30%–40% of dietary absorption takes place in the small intestine, less in the duodenum than in the ileum [5].


Magnesium Deficiency Ethacrynic Acid Renal Handling Magnesium Transport Magnesium Excretion 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • J. H. Dirks
  • N. L. M. Wong

There are no affiliations available

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